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grant_code:"202905/Z/16/Z"

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Current Database

  • EMDB [19]

Current status

  • REL [19]

Sample type

  • Complex [19]
  • Protein [17]
  • Ligand [14]

Organism

  • Homo sapiens [13]
  • Lama glama [8]
  • Chaetomium thermophilum [4]
  • Mus musculus [3]

EM Method

  • Single-particle [12]
  • Subtomogram averaging [5]
  • Tomography [2]

Resolution

  • < 2Å [2]
  • ≥ 2Å and < 3Å [5]
  • ≥ 3Å and < 4Å [5]
  • ≥ 8Å and < 12Å [5]

Model molecular weight

  • 100-250 kDa [5]
  • 250-500 kDa [11]
  • 500-1000 kDa [1]

Release Date

  • 2022 [10]
  • 2021 [7]
  • 2020 [2]

Author by name

  • Aricescu AR [12]
  • Chirgadze DY [12]
  • Hardwick SW [12]
  • Malinauskas T [12]
  • Masiulis S [12]
  • Miehling J [12]
  • Sente A [12]
  • Desai R [10]
  • Jounaidi Y [10]
  • Miller KW [10]
  • Naydenova K [10]
  • Zhou X [10]
  • Briggs JAG [7]
  • Kovtun O [7]
  • Leneva N [7]
  • Morado DR [7]
  • Owen DJ [7]
  • Bischoff M [2]
  • Brown PMGE [2]
  • Grigoras IT [2]
  • Karia D [2]
  • Keizer J [2]
  • Kotecha A [2]
  • Malinauskaite L [2]
  • Mccormack J [2]
  • Mcmullan G [2]
  • Murshudov G [2]
  • Nakane T [2]
  • Pechnikova EV [2]
  • Scheres SHW [2]
  • Tiemeijer P [2]
  • Uchanski T [2]
  • Yu L [2]
  • De Jong E [2]

Author by ORCID

  • Sente A [12]
  • Hardwick SW [12]
  • Chirgadze DY [12]
  • Malinauskas T [12]
  • Aricescu AR [12]
  • Jounaidi Y [10]
  • Miller KW [10]
  • Kovtun O [7]
  • Leneva N [7]
  • Owen DJ [7]
  • Briggs JAG [7]
  • Morado DR [7]
  • Uchanski T [2]
  • Scheres SHW [2]
  • Kotecha A [2]
  • Nakane T [2]
  • Malinauskaite L [2]

Journal

  • NATURE [12]
  • SCI ADV [7]

Software

  • RELION [12]

Microscope

  • FEI TITAN KRIOS [19]

Electron Source

  • FIELD EMISSION GUN [19]

Film or detector model

  • GATAN K3 6K X 4K [10]
  • GATAN K2 QUANTUM 4K X 4K [4]
  • GATAN K3 BIOQUANTUM 6K X 4K [3]
  • FEI FALCON IV 4K X 4K [2]

External links

  • EMPIAR [18]
  • AlphaFold DB [17]
  • Gene Ontology [17]
  • InterPro [17]
  • PDB [17]
  • PDBe-Kb [17]
  • Pfam [17]
  • UniProt [17]
  • ChEBI [12]
  • ChEMBL [12]
  • DrugBank [12]
  • Complex Portal [11]
  • SCOP2 [1]
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Showing 1 - 10 of 19. Page 1 of 2
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EMD-14067
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EMPIAR-10913
Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA A R in complex with nanobody Nb25
Release date: April 13, 2022
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7qn5
Q-score: 0.58

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14068
Download Map
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Raw data
EMPIAR-10913
Cryo-EM structure of human full-length beta3delta GABA A R in complex with nanobody Nb25
Release date: April 13, 2022
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7qn6
Q-score: 0.527

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14069
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EMPIAR-10911 EMPIAR-10914
Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA A R in complex with GABA, histamine and nanobody Nb25
Release date: April 13, 2022
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7qn7
Q-score: 0.548

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14070
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Raw data
EMPIAR-10914
Cryo-EM structure of human full-length beta3delta GABA A R in complex with histamine and nanobody Nb25
Release date: April 13, 2022
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7qn8
Q-score: 0.492

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14071
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Raw data
EMPIAR-10911
Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA A R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state
Release date: April 13, 2022
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7qn9
Q-score: 0.505

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14072
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EMPIAR-10909
Cryo-EM structure of human full-length alpha4beta3gamma2 GABA A R in complex with GABA and nanobody Nb25
Release date: April 13, 2022
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7qna
Q-score: 0.483

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14073
Download Map
3D View
Raw data
EMPIAR-10909
Cryo-EM structure of human full-length beta3gamma2 GABA A R in complex with GABA and nanobody Nb25
Release date: April 13, 2022
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7qnb
Q-score: 0.456

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14074
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Raw data
EMPIAR-10910
Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA A R in complex with THIP gaboxadol , histamine and nanobody Nb25
Release date: April 13, 2022
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7qnc
Q-score: 0.523

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14075
Download Map
3D View
Raw data
EMPIAR-10910
Cryo-EM structure of human full-length extrasynaptic beta3delta GABA A R in complex with THIP gaboxadol , histamine and nanobody Nb25
Release date: April 13, 2022
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7qnd
Q-score: 0.435

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

EMD-14076
Download Map
3D View
Raw data
EMPIAR-10912
Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA A R in complex with Ro15-4513 and megabody Mb38
Release date: April 13, 2022
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7qne
Q-score: 0.606

Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR

Nature (2022) 604 pp. 190-194 [ DOI: doi:10.1038/s41586-022-04517-3 Pubmed: 35355020 ]

Sort by: Download
Showing 1 - 10 of 19. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [19]

Current status

  • REL [19]

Sample type

  • Complex [19]
  • Protein [17]
  • Ligand [14]

Organism

  • Homo sapiens [13]
  • Lama glama [8]
  • Chaetomium thermophilum [4]
  • Mus musculus [3]

EM Method

  • Single-particle [12]
  • Subtomogram averaging [5]
  • Tomography [2]

Resolution

  • < 2Å [2]
  • ≥ 2Å and < 3Å [5]
  • ≥ 3Å and < 4Å [5]
  • ≥ 8Å and < 12Å [5]

Model molecular weight

  • 100-250 kDa [5]
  • 250-500 kDa [11]
  • 500-1000 kDa [1]

Release Date

  • 2022 [10]
  • 2021 [7]
  • 2020 [2]

Author by name

  • Aricescu AR [12]
  • Chirgadze DY [12]
  • Hardwick SW [12]
  • Malinauskas T [12]
  • Masiulis S [12]
  • Miehling J [12]
  • Sente A [12]
  • Desai R [10]
  • Jounaidi Y [10]
  • Miller KW [10]
  • Naydenova K [10]
  • Zhou X [10]
  • Briggs JAG [7]
  • Kovtun O [7]
  • Leneva N [7]
  • Morado DR [7]
  • Owen DJ [7]
  • Bischoff M [2]
  • Brown PMGE [2]
  • Grigoras IT [2]
  • Karia D [2]
  • Keizer J [2]
  • Kotecha A [2]
  • Malinauskaite L [2]
  • Mccormack J [2]
  • Mcmullan G [2]
  • Murshudov G [2]
  • Nakane T [2]
  • Pechnikova EV [2]
  • Scheres SHW [2]
  • Tiemeijer P [2]
  • Uchanski T [2]
  • Yu L [2]
  • De Jong E [2]

Author by ORCID

  • Sente A [12]
  • Hardwick SW [12]
  • Chirgadze DY [12]
  • Malinauskas T [12]
  • Aricescu AR [12]
  • Jounaidi Y [10]
  • Miller KW [10]
  • Kovtun O [7]
  • Leneva N [7]
  • Owen DJ [7]
  • Briggs JAG [7]
  • Morado DR [7]
  • Uchanski T [2]
  • Scheres SHW [2]
  • Kotecha A [2]
  • Nakane T [2]
  • Malinauskaite L [2]

Journal

  • NATURE [12]
  • SCI ADV [7]

Software

  • RELION [12]

Microscope

  • FEI TITAN KRIOS [19]

Electron Source

  • FIELD EMISSION GUN [19]

Film or detector model

  • GATAN K3 6K X 4K [10]
  • GATAN K2 QUANTUM 4K X 4K [4]
  • GATAN K3 BIOQUANTUM 6K X 4K [3]
  • FEI FALCON IV 4K X 4K [2]

External links

  • EMPIAR [18]
  • AlphaFold DB [17]
  • Gene Ontology [17]
  • InterPro [17]
  • PDB [17]
  • PDBe-Kb [17]
  • Pfam [17]
  • UniProt [17]
  • ChEBI [12]
  • ChEMBL [12]
  • DrugBank [12]
  • Complex Portal [11]
  • SCOP2 [1]