Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-14072

Single-particle
3.0 Å
EMD-14072
3D View Gallery
Deposition: 20/12/2021
Map released: 13/04/2022
Last modified: 09/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-14072
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7qna summary report (pdf.gz) Map and 7qna FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25

EMD-14072

Single-particle
3.0 Å
EMD-14072
3D View Gallery
Deposition: 20/12/2021
Map released: 13/04/2022
Last modified: 09/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: Human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and Nanobody Nb25
Fitted models: 7qna

Deposition Authors: Sente A , Desai R
Differential assembly diversifies GABA A receptor structures and signalling.
Sente A , Desai R, Naydenova K, Malinauskas T , Jounaidi Y , Miehling J, Zhou X, Masiulis S, Hardwick SW , Chirgadze DY , Miller KW , Aricescu AR
(2022) Nature , 604 , 190 - 194
PUBMED: 35355020
DOI: doi:10.1038/s41586-022-04517-3
ISSN: 1476-4687
ASTM: NATUAS