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grant_code:"1155302"

Filter By

Current Database

  • EMDB [44]

Current status

  • REL [44]

Sample type

  • Complex [44]
  • Protein [44]
  • Ligand [28]

Organism

  • Homo sapiens [44]
  • Lama glama [40]
  • Synthetic construct [6]
  • Rattus norvegicus [5]
  • Salmo salar [3]

EM Method

  • Single-particle [44]

Resolution

  • < 2Å [1]
  • ≥ 2Å and < 3Å [23]
  • ≥ 3Å and < 4Å [20]

Model molecular weight

  • 100-250 kDa [44]

Release Date

  • 2025 [16]
  • 2024 [3]
  • 2023 [9]
  • 2022 [15]
  • 2021 [1]

Author by name

  • Sexton PM [44]
  • Wootten D [44]
  • Belousoff MJ [38]
  • Johnson RM [25]
  • Cao J [24]
  • Fletcher MM [22]
  • Deganutti G [21]
  • Danev R [20]
  • Wootten DL [17]
  • Christopoulos A [15]
  • Christopoulos G [14]
  • Piper SJ [14]
  • Liang YL [13]
  • Mariam Z [13]
  • Cary BP [12]
  • Josephs TM [11]
  • Ballarin-gonzalez B [10]
  • Bayly-jones C [10]
  • Glendorf T [10]
  • Hay DL [10]
  • Hick CA [10]
  • Keov P [10]
  • Raun K [10]
  • Reedtz-runge S [10]
  • Zhao P [10]
  • Sexton P [7]
  • Reynolds CA [6]
  • Russell IC [6]
  • Gellman SH [5]
  • Gerrard EJ [5]
  • Jiang Y [5]
  • Lu J [5]
  • Besenius M [4]
  • Dal Maso E [4]
  • Evers A [4]
  • Gerrard E [4]
  • Li Z [4]
  • Lorenz K [4]
  • Nettleton TJ [4]
  • Schreuder H [4]
  • Tiwari G [4]
  • Venugopal H [4]
  • Hager MV [3]
  • Hossain MA [3]
  • Humphrys LJ [3]
  • Julita V [3]
  • Li M [3]
  • Li Y [3]
  • Lu JJ [3]
  • Lu Y [3]
  • Morris RK [3]
  • Desai AJ [2]
  • Dong M [2]
  • Furness SGB [2]
  • Harikumar KG [2]
  • Liu X [2]
  • Miller LJ [2]
  • Mobbs JI [2]
  • Toufaily C [2]
  • Truong TT [2]
  • Xu X [2]
  • Zhang X [2]
  • Bumbak F [1]
  • Flocco MM [1]
  • Langmead CJ [1]
  • Leeming MG [1]
  • Mcneill SM [1]
  • Mobbs JM [1]
  • Radostin D [1]
  • Vandekolk TH [1]

Author by ORCID

  • Wootten D [38]
  • Sexton PM [37]
  • Belousoff MJ [32]
  • Cao J [24]
  • Deganutti G [21]
  • Danev R [20]
  • Fletcher MM [13]
  • Christopoulos A [13]
  • Cary BP [12]
  • Josephs TM [11]
  • Liang YL [10]
  • Raun K [10]
  • Keov P [10]
  • Glendorf T [10]
  • Bayly-jones C [10]
  • Reedtz-runge S [10]
  • Hay DL [10]
  • Christopoulos G [10]
  • Hick CA [10]
  • Ballarin-gonzalez B [10]
  • Piper SJ [8]
  • Reynolds CA [6]
  • Russell IC [6]
  • Gellman SH [5]
  • Gerrard EJ [5]
  • Tiwari G [4]
  • Schreuder H [4]
  • Hossain MA [3]
  • Zhao P [3]
  • Nettleton TJ [3]
  • Xu X [2]
  • Liu X [2]
  • Leeming MG [1]
  • Zhang X [1]
  • Mcneill SM [1]
  • Bumbak F [1]
  • Langmead CJ [1]

Journal

  • NAT COMMUN [13]
  • SCIENCE [10]
  • NAT CHEM BIOL [6]
  • PNAS [6]
  • STRUCTURE [5]
  • PLOS BIOL [2]
  • BIOCHEM BIOPHYS RES COMMUN [1]
  • BIOCHEMISTRY [1]
  • BIORXIV [1]

Software

  • CRYOSPARC [20]
  • RELION [7]
  • GCTF [1]

Microscope

  • TFS GLACIOS [18]
  • TFS KRIOS [13]
  • FEI TITAN KRIOS [12]
  • FEI TITAN [1]

Electron Source

  • FIELD EMISSION GUN [44]

Film or detector model

  • FEI FALCON IV 4K X 4K [17]
  • GATAN K3 BIOQUANTUM 6K X 4K [17]
  • GATAN K3 6K X 4K [8]
  • TFS FALCON 4I 4K X 4K [2]

External links

  • AlphaFold DB [44]
  • Gene Ontology [44]
  • PDB [44]
  • PDBe-Kb [44]
  • Pfam [44]
  • UniProt [44]
  • InterPro [41]
  • ChEBI [25]
  • ChEMBL [25]
  • DrugBank [20]
  • Complex Portal [3]
Sort by: Download
Showing 1 - 10 of 44. Page 1 of 5
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Preview first 10
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EMD-71396
Download Map
3D View
Cryo-EM structure of the PAC1nR-VIP-Gs complex
Release date: Nov. 19, 2025
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9p92
Q-score: 0.393

Lu JJ, Deganutti G, Li M, Humphrys LJ, Li Y, Nettleton TJ, Venugopal H, Julita V, Christopoulos G, Reynolds CA, Sexton PM, Wootten D, Zhao P, Piper SJ

PNAS (2025) 122 pp. e2521157122-e2521157122 [ Pubmed: 41264251 DOI: doi:10.1073/pnas.2521157122 ]

EMD-71397
Download Map
3D View
Cryo-EM structure of the PAC1sR-VIP-Gs complex
Release date: Nov. 19, 2025
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9p93
Q-score: 0.441

Lu JJ, Deganutti G, Li M, Humphrys LJ, Li Y, Nettleton TJ, Venugopal H, Julita V, Christopoulos G, Reynolds CA, Sexton PM, Wootten D, Zhao P, Piper SJ

PNAS (2025) 122 pp. e2521157122-e2521157122 [ Pubmed: 41264251 DOI: doi:10.1073/pnas.2521157122 ]

EMD-71398
Download Map
3D View
Cryo-EM structure of the PAC1sR-PACAP27-Gs complex
Release date: Nov. 19, 2025
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9p94
Q-score: 0.499

Lu JJ, Deganutti G, Li M, Humphrys LJ, Li Y, Nettleton TJ, Venugopal H, Julita V, Christopoulos G, Reynolds CA, Sexton PM, Wootten D, Zhao P, Piper SJ

PNAS (2025) 122 pp. e2521157122-e2521157122 [ Pubmed: 41264251 DOI: doi:10.1073/pnas.2521157122 ]

EMD-44760
Download Map
3D View
Human Amylin1 Receptor in complex with Gs and cagrilintide
Release date: April 23, 2025
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 9bp3
Q-score: 0.564

Cao J, Belousoff MJ, Johnson RM, Keov P, Mariam Z, Deganutti G, Christopoulos G, Hick CA, Reedtz-Runge S, Glendorf T, Ballarin-Gonzalez B, Raun K, Bayly-Jones C, Wootten D, Sexton PM

Nat Commun (2025) 16 pp. 3389-3389 [ Pubmed: 40204768 DOI: doi:10.1038/s41467-025-58680-y ]

EMD-44796
Download Map
3D View
Human Amylin2 Receptor in Complex with Gs and Cagrilintide
Release date: April 23, 2025
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9bq3
Q-score: 0.48

Cao J, Belousoff MJ, Johnson RM, Keov P, Mariam Z, Deganutti G, Christopoulos G, Hick CA, Reedtz-Runge S, Glendorf T, Ballarin-Gonzalez B, Raun K, Bayly-Jones C, Wootten D, Sexton PM

Nat Commun (2025) 16 pp. 3389-3389 [ Pubmed: 40204768 DOI: doi:10.1038/s41467-025-58680-y ]

EMD-44904
Download Map
3D View
Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation
Release date: April 23, 2025
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 9bub
Q-score: 0.609

Cao J, Belousoff MJ, Johnson RM, Keov P, Mariam Z, Deganutti G, Christopoulos G, Hick CA, Reedtz-Runge S, Glendorf T, Ballarin-Gonzalez B, Raun K, Bayly-Jones C, Wootten D, Sexton PM

Nat Commun (2025) 16 pp. 3389-3389 [ Pubmed: 40204768 DOI: doi:10.1038/s41467-025-58680-y ]

EMD-44905
Download Map
3D View
Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation repeat
Release date: April 23, 2025
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9buc
Q-score: 0.461

Cao J, Belousoff MJ, Johnson RM, Keov P, Mariam Z, Deganutti G, Christopoulos G, Hick CA, Reedtz-Runge S, Glendorf T, Ballarin-Gonzalez B, Raun K, Bayly-Jones C, Wootten D, Sexton PM

Nat Commun (2025) 16 pp. 3389-3389 [ Pubmed: 40204768 DOI: doi:10.1038/s41467-025-58680-y ]

EMD-44906
Download Map
3D View
Human calcitonin Receptor in complex with Gs and cagrilintide in the CT-like conformation
Release date: April 23, 2025
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9bud
Q-score: 0.558

Cao J, Belousoff MJ, Johnson RM, Keov P, Mariam Z, Deganutti G, Christopoulos G, Hick CA, Reedtz-Runge S, Glendorf T, Ballarin-Gonzalez B, Raun K, Bayly-Jones C, Wootten D, Sexton PM

Nat Commun (2025) 16 pp. 3389-3389 [ Pubmed: 40204768 DOI: doi:10.1038/s41467-025-58680-y ]

EMD-44652
Download Map
3D View
Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone non-acylated in bypass conformation
Release date: April 16, 2025
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9blb
Q-score: 0.486

Cao J, Belousoff MJ, Johnson RM, Keov P, Mariam Z, Deganutti G, Christopoulos G, Hick CA, Reedtz-Runge S, Glendorf T, Ballarin-Gonzalez B, Raun K, Bayly-Jones C, Wootten D, Sexton PM

Nat Commun (2025) 16 pp. 3389-3389 [ Pubmed: 40204768 DOI: doi:10.1038/s41467-025-58680-y ]

EMD-44653
Download Map
3D View
Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone non-acylated in CT-like conformation
Release date: April 16, 2025
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9blc
Q-score: 0.473

Cao J, Belousoff MJ, Johnson RM, Keov P, Mariam Z, Deganutti G, Christopoulos G, Hick CA, Reedtz-Runge S, Glendorf T, Ballarin-Gonzalez B, Raun K, Bayly-Jones C, Wootten D, Sexton PM

Nat Commun (2025) 16 pp. 3389-3389 [ Pubmed: 40204768 DOI: doi:10.1038/s41467-025-58680-y ]

Sort by: Download
Showing 1 - 10 of 44. Page 1 of 5
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [44]

Current status

  • REL [44]

Sample type

  • Complex [44]
  • Protein [44]
  • Ligand [28]

Organism

  • Homo sapiens [44]
  • Lama glama [40]
  • Synthetic construct [6]
  • Rattus norvegicus [5]
  • Salmo salar [3]

EM Method

  • Single-particle [44]

Resolution

  • < 2Å [1]
  • ≥ 2Å and < 3Å [23]
  • ≥ 3Å and < 4Å [20]

Model molecular weight

  • 100-250 kDa [44]

Release Date

  • 2025 [16]
  • 2024 [3]
  • 2023 [9]
  • 2022 [15]
  • 2021 [1]

Author by name

  • Sexton PM [44]
  • Wootten D [44]
  • Belousoff MJ [38]
  • Johnson RM [25]
  • Cao J [24]
  • Fletcher MM [22]
  • Deganutti G [21]
  • Danev R [20]
  • Wootten DL [17]
  • Christopoulos A [15]
  • Christopoulos G [14]
  • Piper SJ [14]
  • Liang YL [13]
  • Mariam Z [13]
  • Cary BP [12]
  • Josephs TM [11]
  • Ballarin-gonzalez B [10]
  • Bayly-jones C [10]
  • Glendorf T [10]
  • Hay DL [10]
  • Hick CA [10]
  • Keov P [10]
  • Raun K [10]
  • Reedtz-runge S [10]
  • Zhao P [10]
  • Sexton P [7]
  • Reynolds CA [6]
  • Russell IC [6]
  • Gellman SH [5]
  • Gerrard EJ [5]
  • Jiang Y [5]
  • Lu J [5]
  • Besenius M [4]
  • Dal Maso E [4]
  • Evers A [4]
  • Gerrard E [4]
  • Li Z [4]
  • Lorenz K [4]
  • Nettleton TJ [4]
  • Schreuder H [4]
  • Tiwari G [4]
  • Venugopal H [4]
  • Hager MV [3]
  • Hossain MA [3]
  • Humphrys LJ [3]
  • Julita V [3]
  • Li M [3]
  • Li Y [3]
  • Lu JJ [3]
  • Lu Y [3]
  • Morris RK [3]
  • Desai AJ [2]
  • Dong M [2]
  • Furness SGB [2]
  • Harikumar KG [2]
  • Liu X [2]
  • Miller LJ [2]
  • Mobbs JI [2]
  • Toufaily C [2]
  • Truong TT [2]
  • Xu X [2]
  • Zhang X [2]
  • Bumbak F [1]
  • Flocco MM [1]
  • Langmead CJ [1]
  • Leeming MG [1]
  • Mcneill SM [1]
  • Mobbs JM [1]
  • Radostin D [1]
  • Vandekolk TH [1]

Author by ORCID

  • Wootten D [38]
  • Sexton PM [37]
  • Belousoff MJ [32]
  • Cao J [24]
  • Deganutti G [21]
  • Danev R [20]
  • Fletcher MM [13]
  • Christopoulos A [13]
  • Cary BP [12]
  • Josephs TM [11]
  • Liang YL [10]
  • Raun K [10]
  • Keov P [10]
  • Glendorf T [10]
  • Bayly-jones C [10]
  • Reedtz-runge S [10]
  • Hay DL [10]
  • Christopoulos G [10]
  • Hick CA [10]
  • Ballarin-gonzalez B [10]
  • Piper SJ [8]
  • Reynolds CA [6]
  • Russell IC [6]
  • Gellman SH [5]
  • Gerrard EJ [5]
  • Tiwari G [4]
  • Schreuder H [4]
  • Hossain MA [3]
  • Zhao P [3]
  • Nettleton TJ [3]
  • Xu X [2]
  • Liu X [2]
  • Leeming MG [1]
  • Zhang X [1]
  • Mcneill SM [1]
  • Bumbak F [1]
  • Langmead CJ [1]

Journal

  • NAT COMMUN [13]
  • SCIENCE [10]
  • NAT CHEM BIOL [6]
  • PNAS [6]
  • STRUCTURE [5]
  • PLOS BIOL [2]
  • BIOCHEM BIOPHYS RES COMMUN [1]
  • BIOCHEMISTRY [1]
  • BIORXIV [1]

Software

  • CRYOSPARC [20]
  • RELION [7]
  • GCTF [1]

Microscope

  • TFS GLACIOS [18]
  • TFS KRIOS [13]
  • FEI TITAN KRIOS [12]
  • FEI TITAN [1]

Electron Source

  • FIELD EMISSION GUN [44]

Film or detector model

  • FEI FALCON IV 4K X 4K [17]
  • GATAN K3 BIOQUANTUM 6K X 4K [17]
  • GATAN K3 6K X 4K [8]
  • TFS FALCON 4I 4K X 4K [2]

External links

  • AlphaFold DB [44]
  • Gene Ontology [44]
  • PDB [44]
  • PDBe-Kb [44]
  • Pfam [44]
  • UniProt [44]
  • InterPro [41]
  • ChEBI [25]
  • ChEMBL [25]
  • DrugBank [20]
  • Complex Portal [3]