Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-44653
Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation
EMD-44653
Single-particle3.3 Å
Deposition: 30/04/2024Map released: 16/04/2025
Last modified: 29/10/2025
Sample Organism:
Homo sapiens,
Lama glama
Sample: Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation
Fitted models: 9blc
Deposition Authors: Cao J
,
Belousoff MJ ,
Wootten DL,
Sexton PM
Sample: Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation
Fitted models: 9blc
Deposition Authors: Cao J
,
Belousoff MJ ,
Wootten DL,
Sexton PM
Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors.
Cao J ,
Belousoff MJ ,
Johnson RM,
Keov P ,
Mariam Z,
Deganutti G ,
Christopoulos G ,
Hick CA ,
Reedtz-Runge S ,
Glendorf T ,
Ballarin-Gonzalez B ,
Raun K ,
Bayly-Jones C ,
Wootten D ,
Sexton PM
(2025) Nat Commun , 16 , 3389 - 3389
,
Belousoff MJ ,
Johnson RM,
Keov P ,
Mariam Z,
Deganutti G ,
Christopoulos G ,
Hick CA ,
Reedtz-Runge S ,
Glendorf T ,
Ballarin-Gonzalez B ,
Raun K ,
Bayly-Jones C ,
Wootten D ,
Sexton PM
(2025) Nat Commun , 16 , 3389 - 3389
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): 1154434 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 2025694 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1155302 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 2026300 (Australia)
- Australian Research Council (ARC): IC200100052 (Australia)