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Integrin AlphaIIbBeta3 Headpiece Bound to a Chimeric Fibrinogen Gamma chain peptide, HHLGGAKQRGDV

X-ray diffraction
2.59Å resolution
PDB entry 2vdq coloured by chain, front view.
PDB entry 2vdq coloured by chain, side view.
PDB entry 2vdq coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Integrin alphaIIb-beta3 complex and Fibrinogen gamma chain
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Multimeric state: hetero pentamer
Accessible surface area: 58236.11 Å2
Buried surface area: 13689.36 Å2
Dissociation area: 897.54 Å2
Dissociation energy (ΔGdiss): -3.16 kcal/mol
Dissociation entropy (TΔSdiss): 14.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208770

Macromolecules

Integrin alpha-IIb heavy chain
Chain: A
Length: 452 amino acids
Theoretical weight: 49.03 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08514 (Residues: 32-483; Coverage: 45%)
Gene names: GP2B, ITGA2B, ITGAB
Pfam: FG-GAP repeat
InterPro:
CATH: Integrin alpha, N-terminal
Integrin alpha-IIb heavy chain in PDB entry 2vdq, assembly 1, front view.
Integrin alpha-IIb heavy chain in PDB entry 2vdq, assembly 1, side view.
Integrin alpha-IIb heavy chain in PDB entry 2vdq, assembly 1, top view.
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Integrin beta-3
Chain: B
Length: 461 amino acids
Theoretical weight: 50.97 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05106 (Residues: 27-487; Coverage: 61%)
Gene names: GP3A, ITGB3
Pfam:
InterPro:
CATH:
Integrin beta-3 in PDB entry 2vdq, assembly 1, front view.
Integrin beta-3 in PDB entry 2vdq, assembly 1, side view.
Integrin beta-3 in PDB entry 2vdq, assembly 1, top view.
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Fibrinogen gamma chain
Chain: C
Length: 12 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02679 (Residues: 426-433; Coverage: 2%)
Gene names: FGG, PRO2061
Fibrinogen gamma chain in PDB entry 2vdq, assembly 1, front view.
Fibrinogen gamma chain in PDB entry 2vdq, assembly 1, side view.
Fibrinogen gamma chain in PDB entry 2vdq, assembly 1, top view.
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MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN
Chain: H
Length: 221 amino acids
Theoretical weight: 23.77 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN in PDB entry 2vdq, assembly 1, front view.
MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN in PDB entry 2vdq, assembly 1, side view.
MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN in PDB entry 2vdq, assembly 1, top view.
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MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN
Chain: L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN in PDB entry 2vdq, assembly 1, front view.
MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN in PDB entry 2vdq, assembly 1, side view.
MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN in PDB entry 2vdq, assembly 1, top view.
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