Domain

Integrin beta, epidermal growth factor-like domain 1 (IPR040622)

Short name: I-EGF_1

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This is the I-EGF domain 1 found in several integrin beta subunits. Structural analysis revealed the presence of four integrin epidermal growth factor-like (I-EGF) domains in integrin beta [PMID: 17201681]. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains; this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end [PMID: 26936951].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam