Domain

Integrin domain (IPR032695)

Short name: Integrin_dom

Domain relationships

Description

Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [PMID: 12297042, PMID: 12361595]. The integrin receptors are composed of alpha and beta subunit heterodimers. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.

Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits [PMID: 12234368]. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans [PMID: 14689578]. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule [PMID: 2467745]. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.

This entry represent the C-terminal domain of integrin alpha (which can be further subdivided in the thight, calf-1 and calf-2 domains) and the central region of integrin beta known as the hybrid domain [PMID: 15378069].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY