Repeat

FG-GAP repeat (IPR013517)

Short name: FG-GAP

Description

This region contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure [PMID: 7929213]. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat [PMID: 7929213]. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding [PMID: 8990162]. A putative Ca2+ binding motif is found in some of the repeats.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
Pfam