Pathways & interactions
Immunoglobulin-like fold (IPR013783)
Short name: Ig-like_fold
- Immunoglobulin-like fold (IPR013783)
- Fibronectin, type III (IPR003961)
- Immunoglobulin-like domain (IPR007110)
- Natural killer cell receptor 2B4 immunoglobulin domain (IPR024303)
- Transglutaminase, N-terminal (IPR001102)
This entry represents domains with an immunoglobulin-like (Ig-like) fold, which consists of a beta-sandwich of seven or more strands in two sheets with a Greek-key topology. Ig-like domains are one of the most common protein modules found in animals, occurring in a variety of different proteins. These domains are often involved in interactions, commonly with other Ig-like domains via their beta-sheets [PMID: 7932691, PMID: 10436082, PMID: 15327963, PMID: 10698639]. Domains within this fold-family share the same structure, but can diverge with respect to their sequence. Based on sequence, Ig-like domains can be classified as V-set domains (antibody variable domain-like), C1-set domains (antibody constant domain-like), C2-set domains, and I-set domains (antibody intermediate domain-like). Proteins can contain more than one of these types of Ig-like domains. For example, in the human T-cell receptor antigen CD2, domain 1 (D1) is a V-set domain, while domain 2 (D2) is a C2-set domain, both domains having the same Ig-like fold [PMID: 7994575].
Domains with an Ig-like fold can be found in many, diverse proteins in addition to immunoglobulin molecules. For example, Ig-like domains occur in several different types of receptors (such as various T-cell antigen receptors), several cell adhesion molecules, MHC class I and II antigens, as well as the hemolymph protein hemolin, and the muscle proteins titin, telokin and twitchin.
- G3DSA:220.127.116.11 (G3DSA:18.104.22.168)