Domain

PSI domain (IPR016201)

Short name: PSI

Domain relationships

Description

This domain is found in several different extracellular receptors, including plexins, which are involved in the development of neural and epithelial tissues [PMID: 17855350]; in semaphorins, which regulate axon guidance, immune function and angiogenesis [PMID: 12958590]; in integrins, which are important Metazoan adhesion receptors that transmit conformational change bidirectionally across the membrane (integrin alpha and beta subunits form a head and two long legs in the ectodomain and span the membrane) [PMID: 15378069]; and in hepatocyte growth factor receptor, which plays important roles in normal development and in tumour growth and metastasis [PMID: 15167892].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART