EMDB EMD-8560

Single particle reconstruction
3.34Å resolution

Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4

Map released:
Last modified:
Overview of EMD-8560
Source organism: Bos taurus [9913]
Fitted atomic model: 5uja
Related EM entry by publication: EMD-8559
Primary publication:
Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.
Johnson ZL, Chen J
Cell 168 1075-1085.e9 (2017)
PMID: 28238471

Function and Biology Details

Sample name: bovine multidrug resistance protein 1 (MRP1) complexed with leukotriene C4
Ligand: (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid
Proteins: bovine multidrug resistance protein 1 (MRP1) complexed with leukotriene C4, bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1

Experimental Information Details

Resolution: 3.34Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: FREALIGN
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)