5uja

Electron Microscopy
3.34Å resolution

Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4

Released:
Source organism: Bos taurus
Related structures: EMD-8560

Function and Biology Details

Reactions catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug resistance-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 1460 amino acids
Theoretical weight: 159.7 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8HXQ5 (Residues: 205-1530; Coverage: 87%)
Gene names: ABCC1, MRP1
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.34Å
Relevant EMDB volumes: EMD-8560
Expression system: Homo sapiens