EMDB EMD-8512

Single particle reconstruction
3.51Å resolution

Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP

Map released:
Last modified:
Overview of EMD-8512
Source organism: Homo sapiens [9606]
Fitted atomic model: 5u6p
Related EM entry by publication: EMD-8511
Primary publication:
Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Lee CH, MacKinnon R
Cell 168 111-120.e11 (2017)
PMID: 28086084

Function and Biology Details

Sample name: Human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Cellular component: Human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Ligand: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Proteins: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 11, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 11

Experimental Information Details

Resolution: 3.51Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)