5u6p

Electron Microscopy
3.51Å resolution

Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP

Released:
Source organism: Homo sapiens
Primary publication:
Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Cell 168 111-120.e11 (2017)
PMID: 28086084
Related structures: EMD-8512

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only octamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 660 amino acids
Theoretical weight: 74.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60741 (Residues: 1-890; Coverage: 74%)
Gene names: BCNG1, HCN1
Sequence domains:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 11 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 19 amino acids
Theoretical weight: 1.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.51Å
Relevant EMDB volumes: EMD-8512
Expression system: Homo sapiens