Single particle reconstruction
4.7Å resolution

Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization

Map released:
Last modified:
Overview of EMD-6458
Source organism: Mus musculus [10090]
Fitted atomic model: 3jbl
Related EM entry by publication: EMD-6459, EMD-6460
Primary publication:
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H
SCIENCE 350 404-409 (2015)
PMID: 26449474

Function and Biology Details

Sample name: NAIP2/NLRC4 inflammasome, 11-fold disk
Proteins: NLR family CARD domain-containing protein 4, NLR family, apoptosis inhibitory protein 2

Experimental Information Details

Resolution: 4.7Å
Resolution method: FSC 0.143, gold-standard
Applied symmetry: C12
Reconstruction software: Spider, EMAN2, Relion
Microscope: OTHER
Detector: GATAN K2 (4k x 4k)