Electron Microscopy
4.5Å resolution

Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization


Function and Biology Details

Structure analysis Details

Assembly composition:
homo undecamer (preferred)
Entry contents:
1 distinct polypeptide molecule
NLR family CARD domain-containing protein 4 Chains: A, B, C, D, E, F, G, H, I, J, K
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K
Length: 932 amino acids
Theoretical weight: 106.24 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
  • Canonical: Q3UP24 (Residues: 93-1024; Coverage: 91%)
Gene names: Card12, Ipaf, Nlrc4
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 4.5Å
Relevant EMDB volumes: EMD-6458
Expression system: Spodoptera frugiperda