EMDB EMD-4983

Single particle reconstruction
3.5Å resolution

Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1

Map released:
Last modified:
Overview of EMD-4983
Fitted atomic model: 6rqj
Primary publication:
An inhibitor of complement C5 provides structural insights into activation.
Reichhardt MP, Johnson S, Tang T, Morgan T, Tebeka N, Popitsch N, Deme JC, Jore MM, Lea SM
Proc.Natl.Acad.Sci.USA 117 362-370 (2020)
PMID: 31871188

Function and Biology Details

Sample name: Quaternary complex of human complement C5 with tick inhibitors OmCI, RaCI and CirpT1
Ligand: N-ACETYL-D-GLUCOSAMINE
Proteins: Quaternary complex of human complement C5 with tick inhibitors OmCI, RaCI and CirpT1, Human Complement C5 (2), Complement inhibitor, Rhipicephalus appendiculatus RaCI1, Putative 8.9 kDa family member, Complement C5, Complement inhibitor, Rhipicephalus appendiculatus RaCI1, Complement C5, Putative 8.9 kDa family member

Experimental Information Details

Resolution: 3.5Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)