EMD-47335
This entry was superseded by EMD-70618.Cryo-EM focused map masking butyrolactol A binding site of the C. neoformans lipid flippase Apt1-Cdc50 bound with butyrolactol A in the E2P state
EMD-47335
Single-particle2.93 Å
Deposition: 17/10/2024Map released: 05/02/2025
Obsolete date: 14/01/2026
Last modified: 14/01/2026
Sample Organism:
Cryptococcus neoformans var. grubii H99
Sample: Apt1-Cdc50 heterodimer bound with butyrolactol A
Deposition Authors: Duan HD
,
Li H
Sample: Apt1-Cdc50 heterodimer bound with butyrolactol A
Deposition Authors: Duan HD
,
Li H
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.
Chen X,
Duan HD ,
Hoy MJ,
Koteva K,
Spitzer M,
Guitor AK,
Puumala E,
Fiebig AA,
Hu G,
Yiu B,
Chou S,
Bian Z,
Choi Y,
Guo ABY,
Wang W,
Sun S,
Robbins N,
Averette AF,
Cook MA,
Truant R,
MacNeil LT,
Brown ED,
Kronstad JW,
Coombes BK,
Cowen LE,
Heitman J,
Li H ,
Wright GD
(2025) Cell
,
Hoy MJ,
Koteva K,
Spitzer M,
Guitor AK,
Puumala E,
Fiebig AA,
Hu G,
Yiu B,
Chou S,
Bian Z,
Choi Y,
Guo ABY,
Wang W,
Sun S,
Robbins N,
Averette AF,
Cook MA,
Truant R,
MacNeil LT,
Brown ED,
Kronstad JW,
Coombes BK,
Cowen LE,
Heitman J,
Li H ,
Wright GD
(2025) Cell
Grant Support: