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EMD-70618
Cryo-EM structure of the C. neoformans lipid flippase Apt1-Cdc50 bound with butyrolactol A in the E2P state
EMD-70618
Single-particle2.95 Å
Deposition: 14/05/2025Map released: 22/10/2025
Last modified: 22/10/2025
Sample Organism:
Cryptococcus neoformans var. grubii H99
Sample: Apt1-Cdc50 heterodimer bound with butyrolactol A
Fitted models: 9omv
Deposition Authors: Duan HD, Li H
Sample: Apt1-Cdc50 heterodimer bound with butyrolactol A
Fitted models: 9omv
Deposition Authors: Duan HD, Li H
Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition.
Chen X ,
Duan HD,
Hoy MJ,
Koteva K,
Spitzer M,
Guitor AK,
Puumala E,
Fiebig AA,
Hu G,
Yiu B,
Chou S,
Bian Z ,
Choi Y,
Ya Guo AB,
Wang W,
Sun S,
Robbins N,
Averette AF,
Cook MA,
Truant R,
MacNeil LT,
Brown ED,
Kronstad JW,
Coombes BK,
Cowen LE,
Heitman J ,
Li H ,
Wright GD
(2025) bioRxiv
,
Duan HD,
Hoy MJ,
Koteva K,
Spitzer M,
Guitor AK,
Puumala E,
Fiebig AA,
Hu G,
Yiu B,
Chou S,
Bian Z ,
Choi Y,
Ya Guo AB,
Wang W,
Sun S,
Robbins N,
Averette AF,
Cook MA,
Truant R,
MacNeil LT,
Brown ED,
Kronstad JW,
Coombes BK,
Cowen LE,
Heitman J ,
Li H ,
Wright GD
(2025) bioRxiv
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