EMDB EMD-22137

Single particle reconstruction
3.9Å resolution

Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies

Map released:
Last modified:
Overview of EMD-22137
Fitted atomic model: 6xdg
Primary publication:
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.
Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, Yan Y, Koon K, Patel K, Chung KM, Hermann A, Ullman E, Cruz J, Rafique A, Huang T, Fairhurst J, Libertiny C, Malbec M, Lee WY, Welsh R, Farr G, Pennington S, Deshpande D, Cheng J, Watty A, Bouffard P, Babb R, Levenkova N, Chen C, Zhang B, Romero Hernandez A, Saotome K, Zhou Y, Franklin M, Sivapalasingam S, Lye DC, Weston S, Logue J, Haupt R, Frieman M, Chen G, Olson W, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA
Science - (2020)
PMID: 32540901

Function and Biology Details

Sample name: Complex of SARS-CoV-2 spike protein receptor binding domain with Fab fragments of two neutralizing antibodies
Ligands: N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ALPHA-D-MANNOSE
Proteins: Complex of SARS-CoV-2 spike protein receptor binding domain with Fab fragments of two neutralizing antibodies, spike protein receptor binding domain, REGN10933 antibody Fab fragment, REGN10987 antibody Fab fragment, Spike glycoprotein, REGN10933 antibody Fab fragment light chain, REGN10933 antibody Fab fragment heavy chain, REGN10987 antibody Fab fragment heavy chain, REGN10987 antibody Fab fragment light chain

Experimental Information Details

Resolution: 3.9Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: cryoSPARC
Microscope: FEI TITAN KRIOS
Detector: OTHER