EMDB EMD-22009

Single particle reconstruction
3.0Å resolution

Structure of human TRPA1 in complex with agonist GNE551

Map released:
Last modified:
Overview of EMD-22009
Source organism: Homo sapiens [9606]
Fitted atomic model: 6x2j
Primary publication:
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.
Liu C, Reese R, Vu S, Rouge L, Shields SD, Kakiuchi-Kiyota S, Chen H, Johnson K, Shi YP, Chernov-Rogan T, Greiner DMZ, Kohli PB, Hackos D, Brillantes B, Tam C, Li T, Wang J, Safina B, Magnuson S, Volgraf M, Payandeh J, Zheng J, Rohou A, Chen J
Neuron - (2020)
PMID: 33152265

Function and Biology Details

Sample name: TRPA1 bound by agonist GNE551
Ligand: 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide
Proteins: TRPA1 bound by agonist GNE551, Transient receptor potential cation channel subfamily A member 1

Experimental Information Details

Resolution: 3.0Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Reconstruction software: cisTEM
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)