› 6x2j

Electron Microscopy
3Å resolution

Structure of human TRPA1 in complex with agonist GNE551

Released:
DOI: 10.2210/pdb6x2j/pdb
PDB 6x2j coloured by chain and viewed from the front.
PDB 6x2j coloured by chain and viewed from the side.
PDB 6x2j coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.
Liu C, Reese R, Vu S, Rougé L, Shields SD, Kakiuchi-Kiyota S, Chen H, Johnson K, Shi YP, Chernov-Rogan T, Greiner DMZ, Kohli PB, Hackos D, Brillantes B, Tam C, Li T, Wang J, Safina B, Magnuson S, Volgraf M, Payandeh J, Zheng J, Rohou A, Chen J
Neuron (2020)
PMID: 33152265
Related structures: EMD-22009

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily A member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 631 amino acids
Theoretical weight: 72.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75762 (Residues: 448-1078; Coverage: 56%)
Gene names: ANKTM1, TRPA1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ULJ 4 x ULJ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-22009
Expression system: Spodoptera frugiperda

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