EMDB EMD-21512

Single particle reconstruction
3.06Å resolution

Cryo-EM structure of 5HT3A receptor in presence of Ondansetron

Map released:
Overview of EMD-21512
Source organism: Mus musculus [10090]
Fitted atomic model: 6w1m
Related EM entry by publication: EMD-21511, EMD-21518
Primary publication:
High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S
Elife 9 - (2020)
PMID: 33063666

Function and Biology Details

Sample name: Serotonin receptor
Ligand: ondansetron
Proteins: Serotonin receptor, 5-hydroxytryptamine receptor 3A

Experimental Information Details

Resolution: 3.06Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C5
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: OTHER