6w1m

Electron Microscopy
3.06Å resolution

Cryo-EM structure of 5HT3A receptor in presence of Ondansetron

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
5-hydroxytryptamine receptor 3A short splice variant Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 450 amino acids
Theoretical weight: 52.04 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8K1F4 (Residues: 34-483; Coverage: 98%)
Gene name: Htr3a
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.06Å
Relevant EMDB volumes: EMD-21512
Expression system: Spodoptera frugiperda