EMD-14709
Cryo-EM structure of human NKCC1 (TM domain)
EMD-14709
Single-particle2.55 Å
Deposition: 04/04/2022Map released: 05/10/2022
Last modified: 20/11/2024
Sample Organism:
Homo sapiens
Sample: Dimeric NKCC1 in complex with Na+, K+ and 2Cl-
Fitted models: 7zgo
Deposition Authors: Nissen P
,
Fenton R,
Neumann C ,
Lindtoft Rosenbaek L,
Kock Flygaard R,
Habeck M ,
Lykkegaard Karlsen J,
Wang Y ,
Lindorff-Larsen K ,
Gad H,
Hartmann R ,
Lyons J
Sample: Dimeric NKCC1 in complex with Na+, K+ and 2Cl-
Fitted models: 7zgo
Deposition Authors: Nissen P
,
Fenton R,
Neumann C ,
Lindtoft Rosenbaek L,
Kock Flygaard R,
Habeck M ,
Lykkegaard Karlsen J,
Wang Y ,
Lindorff-Larsen K ,
Gad H,
Hartmann R ,
Lyons J
Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.
Neumann C ,
Rosenbaek LL ,
Flygaard RK ,
Habeck M ,
Karlsen JL,
Wang Y ,
Lindorff-Larsen K ,
Gad HH ,
Hartmann R ,
Lyons JA ,
Fenton RA ,
Nissen P
(2022) EMBO J , 41 , e110169 - e110169
,
Rosenbaek LL ,
Flygaard RK ,
Habeck M ,
Karlsen JL,
Wang Y ,
Lindorff-Larsen K ,
Gad HH ,
Hartmann R ,
Lyons JA ,
Fenton RA ,
Nissen P
(2022) EMBO J , 41 , e110169 - e110169
Grant Support:
- Lundbeckfonden: 2015-3225 (Denmark)
- Lundbeckfonden: R310-2018-3713 (Denmark)
- Leducq Foundation: 17CVD05 (France)
- Novo Nordisk Foundation: NNF21OC0067647 (Denmark)
- Novo Nordisk Foundation: NNF17OC0029724 (Denmark)
- Novo Nordisk Foundation: NNF19OC0058439 (Denmark)