EMDB EMD-12806

Single particle reconstruction
3.6Å resolution

Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)

Map released:
Overview of EMD-12806
Source organism: Rattus norvegicus [10116]
Fitted atomic model: 7ocf
Primary publication:
Gating and modulation of a hetero-octameric AMPA glutamate receptor
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature - (2021)

Function and Biology Details

Sample name: GluA1/A2 heterotetramer in complex with auxiliary subunits TARP gamma 8 and CNIH2
Ligands: CYCLOTHIAZIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID
Proteins: GluA1/A2 heterotetramer in complex with auxiliary subunits TARP gamma 8 and CNIH2, Isoform Flip of Glutamate receptor 1, Isoform Flip of Glutamate receptor 2, Protein cornichon homolog 2, Voltage-dependent calcium channel gamma-8 subunit

Experimental Information Details

Resolution: 3.6Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C2
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: OTHER