7ocf

Electron Microscopy
3.6Å resolution

Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)

Released:
Source organism: Rattus norvegicus
Entry authors: Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Related structures: EMD-12806

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Glutamate receptor 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 915 amino acids
Theoretical weight: 102.66 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19490 (Residues: 1-19, 20-907; Coverage: 100%)
  • Best match: P19490-2 (Residues: 1-19, 20-907)
Gene names: Glur1, Gria1
Glutamate receptor 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 860 amino acids
Theoretical weight: 96.25 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-860; Coverage: 97%)
  • Best match: P19491-2 (Residues: 1-860)
Gene names: Glur2, Gria2
Protein cornichon homolog 2 Chains: E, G
Molecule details ›
Chains: E, G
Length: 188 amino acids
Theoretical weight: 22 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5BJU5 (Residues: 1-160; Coverage: 100%)
Gene name: Cnih2
Voltage-dependent calcium channel gamma-8 subunit Chains: I, J
Molecule details ›
Chains: I, J
Length: 423 amino acids
Theoretical weight: 43.58 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8VHW5 (Residues: 2-417; Coverage: 99%)
Gene name: Cacng8

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-12806
Expression system: Homo sapiens