EMDB EMD-0636

Single particle reconstruction
3.2Å resolution

Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, AMTB-bound state

Map released:
Overview of EMD-0636
Source organism: Parus major [9157]
Fitted atomic model: 6o6r
Related EM entries by publication: EMD-0631, EMD-0638, EMD-0639
Primary publication:
Structural insights into TRPM8 inhibition and desensitization.
Diver MM, Cheng Y, Julius D
Science - (2019)
PMID: 31488702

Function and Biology Details

Sample name: Transient receptor potential cation channel subfamily M member 8
Ligands: CHOLESTEROL HEMISUCCINATE, UNDECANE, (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, SODIUM ION
Proteins: Transient receptor potential cation channel subfamily M member 8, Transient receptor potential cation channel subfamily M member 8

Experimental Information Details

Resolution: 3.2Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)