› 6o6r

Electron Microscopy
3.2Å resolution

Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, AMTB-bound state

Released:
DOI: 10.2210/pdb6o6r/pdb
PDB entry 6o6r coloured by chain, front view.
PDB entry 6o6r coloured by chain, side view.
PDB entry 6o6r coloured by chain, top view.
Source organism: Parus major
Primary publication:
Structural insights into TRPM8 inhibition and desensitization.
Diver MM, Cheng Y, Julius D
Science 365 1434-1440 (2019)
PMID: 31488702
Related structures: EMD-0636

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167183 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1098 amino acids
Theoretical weight: 126.99 KDa
Source organism: Parus major
Expression system: Homo sapiens

Ligands and Environments

5 bound ligands:
Ligand Y01 4 x Y01
Ligand UND 8 x UND
Ligand 9PE 4 x 9PE
Ligand LQ7 4 x LQ7
Ligand NA 8 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-0636
Expression system: Homo sapiens

Quick links

Citations

24 review citations

Structural mechanisms of transient receptor potential ion channels.
Cao E. (2020)
23 more

14 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
13 more