Substrates for U9G.054: LPXTGase (Streptococcus pyogenes) and similar

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
M protein fragment P19401 538-552 KRQLPSTGE+TANPFY S Ser Thr Gly Glu Thr Ala Asn Pro Lee et al., 2002
M protein fragment P19401 538-552 KRQLPS+TGETANPFY S Gln Leu Pro Ser Thr Gly Glu Thr Lee et al., 2002
Protein A P02976 479-491 Peptide-Thr485+Gly-Glu-Glu-Asn-Pro-Phe-Tyr S CS Leu Pro Glu Thr Gly Glu Glu Asn Lee & Fischetti, 2006
Protein A P02976 479-491 Peptide-Glu487+Glu-Asn-Pro-Phe-Tyr S CS Glu Thr Gly Glu Glu Asn Pro Phe Lee & Fischetti, 2006