Substrates for peptidase S9G.054: profilaggrin endopeptidase 1

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
filaggrin	P11088	1-336	peptide-Tyr151+Tyr-peptide	P	Gly	Ser	Gly	Tyr	Tyr	Tyr	Glu	Gln	Resing et al., 1995
filaggrin	P11088	1-336	peptide-Tyr152+Tyr-peptide	P	Ser	Gly	Tyr	Tyr	Tyr	Glu	Gln	Glu	Resing et al., 1995
profilaggrin	Q99053	1-406	peptide-Tyr311+Tyr-peptide	P	Pro	Gln	Val	Tyr	Tyr	Tyr	Gly	Val	Resing et al., 1995
profilaggrin	Q99053	1-406	peptide-Tyr313+Gly-peptide	P	Val	Tyr	Tyr	Tyr	Gly	Val	Glu	Glu	Resing et al., 1995