Substrates for peptidase S51.001: dipeptidase E

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Asp-Gly-Gly	Asp+Gly-Gly	N	-	-	-	Asp	Gly	Gly	-	-	Miller, 2004
Asp-Leu	Asp+Leu	N	-	-	-	Asp	Leu	-	-	-	Miller, 2004
Asp-NHPhNO2	Asp+NHPhNO2	S	-	-	-	Asp	NAN	-	-	-	Miller, 2004
Asp-Phe-NH2	Asp+Phe-NH2	N	-	-	-	Asp	Phe	NH2	-	-	Miller, 2004
Asp-Phe-NHPhNO2	Asp+Phe-NHPhNO2	S	-	-	-	Asp	Phe	NAN	-	-	Miller, 2004
Asp-Phe-OMe	Asp+Phe-NH2	N	-	-	-	Asp	Phe	OMe	-	-	Miller, 2004
aspartyl-amino acid	Asp+Xaa	N	-	-	-	Asp	Xaa	-	-	-	Miller, 2004