Substrates for peptidase S46.001: dipeptidyl-peptidase 7 (Porphyromonas gingivalis-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ala-Ala-NHPhNO2			Ala-Ala+NPhNO2	S		-	-	Ala	Ala	NAN	-	-	-	Banbula et al., 2001
Ala-Ala-NHPhNO2			Ala-Ala+NHPhNO2	S		-	-	Ala	Ala	NAN	-	-	-	Banbula et al., 2001
Ala-Asn-MCA			Ala-Asn+MCA	S		-	-	Ala	Asn	MCA	-	-	-	Rouf et al., 2013
Ala-Phe-NHPhNO2			Ala-Phe+NPhNO2	S		-	-	Ala	Phe	NAN	-	-	-	Banbula et al., 2001
Ala-Phe-NHPhNO2			Ala-Phe+NHPhNO2	S		-	-	Ala	Phe	NAN	-	-	-	Banbula et al., 2001
gastric inhibitory polypeptide	P09681	52-93	Tyr+Glu-peptide	P	MS	'-'	'-'	Tyr	Ala	Glu	Gly	Thr	Phe	Ohara-Nemoto et al., 2022
gastric inhibitory polypeptide	P09681	54-93	Glu+Thr-peptide	P	MS	'-'	'-'	Glu	Gly	Thr	Phe	Ile	Ser	Ohara-Nemoto et al., 2022
gastric inhibitory polypeptide	P09681	56-93	Thr+Ile-peptide	P	MS	'-'	'-'	Thr	Phe	Ile	Ser	Asp	Tyr	Ohara-Nemoto et al., 2022
gastric inhibitory polypeptide	P09681	58-93	Ile+Asp-peptide	P	MS	'-'	'-'	Ile	Ser	Asp	Tyr	Ser	Ile	Ohara-Nemoto et al., 2022
gastric inhibitory polypeptide	P09681	60-93	Asp+Ser-peptide	P	MS	'-'	'-'	Asp	Tyr	Ser	Ile	Ala	Met	Ohara-Nemoto et al., 2022
gastric inhibitory polypeptide	P09681	62-93	Ser+Ala-peptide	P	MS	'-'	'-'	Ser	Ile	Ala	Met	Asp	Lys	Ohara-Nemoto et al., 2022
gastric inhibitory polypeptide	P09681	64-93	Ala+Asp-peptide	P	MS	'-'	'-'	Ala	Met	Asp	Lys	Ile	His	Ohara-Nemoto et al., 2022
gastric inhibitory polypeptide	P09681	66-93	Asp+Ile-peptide	P	MS	'-'	'-'	Asp	Lys	Ile	His	Gln	Gln	Ohara-Nemoto et al., 2022
Gly-Phe-MCA			Gly-Phe+MCA	S		-	-	Gly	Phe	MCA	-	-	-	Rouf et al., 2013
Gly-Phe-NHPhNO2			Gly-Phe+NPhNO2	S		-	-	Gly	Phe	NAN	-	-	-	Banbula et al., 2001
Gly-Phe-NHPhNO2			Gly-Phe+NHPhNO2	S		-	-	Gly	Phe	NAN	-	-	-	Banbula et al., 2001
Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu			Ile-Ala+Arg-Arg-His-Pro-Tyr-Phe-Leu	N		-	-	Ile	Ala	Arg	Arg	His	Pro	Banbula et al., 2001
Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu			Ile-Ala+Arg-Arg-His-Pro-Tyr-Phe-Leu	S		-	-	Ile	Ala	Arg	Arg	His	Pro	Banbula et al., 2001
Leu-Arg-MCA			Leu-Arg+MCA	S		-	-	Leu	Arg	MCA	-	-	-	Rouf et al., 2013
Leu-Gln-MCA			Leu-Gln+MCA	S		-	-	Leu	Gln	MCA	-	-	-	Rouf et al., 2013
Lys-Ala-MCA			Lys-Ala+MCA	S		-	-	Lys	Ala	MCA	-	-	-	Rouf et al., 2013
Lys-Ile-Ala-Gly-Tyr-His-Leu-Glu-Leu			Lys-Ile+Ala-Gly-Tyr-His-Leu-Glu-Leu	N		-	-	Lys	Ile	Ala	Gly	Tyr	His	Banbula et al., 2001
Lys-Ile-Ala-Gly-Tyr-His-Leu-Glu-Leu			Lys-Ile+Ala-Gly-Tyr-His-Leu-Glu-Leu	S		-	-	Lys	Ile	Ala	Gly	Tyr	His	Banbula et al., 2001
Met-Leu-MCA			Met-Leu+MCA	S		-	-	Met	Leu	MCA	-	-	-	Rouf et al., 2013
Phe-Leu-Arg-Glu-Pro-Val-Ile-Phe-Leu			Phe-Leu+Arg-Glu-Pro-Val-Ile-Phe-Leu	N		-	-	Phe	Leu	Arg	Glu	Pro	Val	Banbula et al., 2001
Phe-Leu-Arg-Glu-Pro-Val-Ile-Phe-Leu			Phe-Leu+Arg-Glu-Pro-Val-Ile-Phe-Leu	S		-	-	Phe	Leu	Arg	Glu	Pro	Val	Banbula et al., 2001
Ser-Tyr-MCA			Ser-Tyr+MCA	S		-	-	Ser	Tyr	MCA	-	-	-	Rouf et al., 2013
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu			Trp-Ala+Gly-Gly-Asp-Ala-Ser-Gly-Glu	N		-	-	Trp	Ala	Gly	Gly	Asp	Ala	Banbula et al., 2001
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu			Trp-Ala+Gly-Gly-Asp-Ala-Ser-Gly-Glu	S		-	-	Trp	Ala	Gly	Gly	Asp	Ala	Banbula et al., 2001