Substrates for peptidase S33.002: tripeptidyl-peptidase A

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Pro-Ala-NHPhNO2 Ala-Pro-Ala+NHPhNO2 S - Ala Pro Ala NAN - - - Butler, 2004
Ala-Pro-Met-NHPhNO2 Ala-Pro-Met+NHPhNO2 S - Ala Pro Met NAN - - - Butler, 2004
Gly-Pro-Leu-NHPhNO2 Gly-Pro-Leu+NHPhNO2 S - Gly Pro Leu NAN - - -
granulocyte-macrophage colony-stimulating factor P04141 18-144 Ala-Pro-Ala3+Arg-peptide P - Ala Pro Ala Arg Ser Pro Ser 17752
Ser-Pro-Ala-NHPhNO2 Ser-Pro-Ala+NHPhNO2 S - Ser Pro Ala NAN - - - Butler, 2004