Substrates for peptidase S26.002: mitochondrial inner membrane peptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
consensus alanyl bond peptide-Pro-Xaa-Ala-Xaa-Ala+peptide N Pro Xaa Ala Xaa Ala CPe - - Packer & Howe, 2004
consensus alanyl bond peptide-Gly-Xaa-Ala-Xaa-Ala+peptide N Gly Xaa Ala Xaa Ala CPe - - Packer & Howe, 2004
cytochrome b2, mitochondrial P00175 1-591 peptide-Asn80+Glu-peptide P NT Gln Ile Asp Asn Glu Pro Lys Leu Pratje & Guiard, 1986
cytochrome C oxidase subunit 2 P00410 1-251 peptide-Asn15+Asp-peptide P NT Phe Ile Met Asn Asp Val Pro Thr Pratje et al., 1983
Glycerol-3-phosphate dehydrogenase, mitochondrial P32191 1-649 Peptide-Asn37+Asp-Peptide P CS Leu Val His Asn Asp Pro Ser Tyr Esser et al., 2004