Substrates for peptidase S12.003: alkaline D-peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Boc-D-Phe-D-Phe	Boc-D-Phe+D-Phe	S	-	-	Boc	DPh	DPh	-	-	-	Asano et al., 1996
Boc-D-Phe-D-Phe-D-Phe	Boc-D-Phe-D-Phe+D-Phe	S	-	Boc	DPh	DPh	DPh	-	-	-	Asano et al., 1996
Boc-D-Phe-D-Phe-D-Phe-D-Phe	Boc-D-Phe-D-Phe+D-Phe-D-Phe	S	-	Boc	DPh	DPh	DPh	DPh	-	-	Asano et al., 1996
Boc-D-Phe-D-Phe-D-Phe-tert-butylester	Boc-D-Phe-D-Phe+D-Phe-tert-butylester	S	-	Boc	DPh	DPh	CBk	-	-	-	Asano et al., 1996
D-Phe-D-Phe-D-Phe	D-Phe-D-Phe+D-Phe	N	-	-	DPh	DPh	DPh	-	-	-	Asano, 2004
D-Phe-D-Phe-D-Phe-D-Phe	D-Phe-D-Phe+D-Phe-D-Phe	N	-	-	DPh	DPh	DPh	DPh	-	-	Asano, 2004
D-Phe-D-Phe-D-Tyr	D-Phe-D-Phe+D-Tyr	N	-	-	DPh	DPh	DTy	-	-	-	Asano et al., 1996
D-Phe-D-Phe-OMe	D-Phe-D-Phe+OMe	S	-	-	DPh	DPh	OMe	-	-	-	Asano et al., 1996
D-Phe-OMe	D-Phe+OMe	N	-	-	-	DPh	OMe	-	-	-	Asano et al., 1996
D-Tyr-D-Phe-D-Phe	D-Tyr-D-Phe+D-Phe	N	-	-	DTy	DPh	DPh	-	-	-	Asano et al., 1996
Phe-D-Phe-D-Phe	Phe-D-Phe+D-Phe	N	-	-	Phe	DPh	DPh	-	-	-	Asano, 2004
Phe-D-Phe-Phe	Phe-D-Phe+Phe	N	-	-	Phe	DPh	Phe	-	-	-	Asano et al., 1996