Substrates for peptidase S09.078: peptide cyclase 1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Precursor 1			peptide-Gly+Phe-peptide	N	MS	Pro	Phe	Tyr	Gly	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1	F6LNL5	14-32	peptide-Ala19+Phe-peptide	P	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Ala22Val)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Ala	Barber et al., 2013
Presegetalin A1 (Ala28Val)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Ala30Val)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Asn27Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Asp24Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (delta25-26)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Ala	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Gln21Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Val	Lys	Barber et al., 2013
Presegetalin A1 (Glu26Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Gly14Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (ins 16Ala17)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Ala	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (ins 16AlaAlaAla17)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Ala	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Lys23Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Phe20Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Ala	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Pro16Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Ala	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Pro16D-Pro)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	DPr	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Pro31Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Ser29Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Trp18Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Ala	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Trp18D-Trp)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	DTr	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Val15Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Val15D-Val)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Val17Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Ala	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Val17D-Val)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	DVa	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Val25Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin A1 (Val32Ala)	F6LNL5	14-32	peptide-Ala19+Phe-peptide	S	MS	Pro	Val	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin B1	F6LNL6	14-31	peptide-Ala18+Phe-peptide	P	MS	Val	Ala	Trp	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin D1	F6LNL7	14-31	peptide-Pro20+Ala-peptide	P	MS	Phe	Ala	Phe	Pro	Ala	Lys	Asp	Ala	Barber et al., 2013
Presegetalin D1 (Pro20Gln)	F6LNL7	14-31	peptide-Ala18+Phe-peptide	S	MS	Leu	Ser	Phe	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin F1	F6LNM3	14-38	peptide-Pro22+Ile-peptide	P	MS	Ser	Ser	Lys	Pro	Gln	Thr	Gln	Val	Barber et al., 2013
Presegetalin G1	F6LNM5	14-31	peptide-Ala18+Phe-peptide	P	MS	Val	Lys	Tyr	Ala	Phe	Gln	Pro	Lys	Barber et al., 2013
Presegetalin H1	F6LNM8	14-31	peptide-Ser18+Phe-peptide	P	MS	Tyr	Arg	Phe	Ser	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin J1	F6LNM4	14-36	peptide-Pro22+Ile-peptide	P	MS	Leu	Pro	Ala	Pro	Ile	Gln	Val	Pro	Barber et al., 2013
Presegetalin K1	F6LNM7	14-31	peptide-Ala18+Phe-peptide	P	MS	Arg	Val	Lys	Ala	Phe	Gln	Ala	Lys	Barber et al., 2013
Presegetalin L1	F6LNM6	14-32	peptide-Pro19+Phe-peptide	P	MS	Pro	Gly	Trp	Pro	Phe	Gln	Ala	Lys	Barber et al., 2013