Substrates for peptidase S09.072: puromycin hydrolase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-NHNap Ala+NHNap S - - - Ala NAP - - - Nishimura et al., 2006
Ala-NHPhNO2 Ala+NHPhNO2 S - - - Ala NAN - - - Arima et al., 2010
beta-Ala-OBzl beta-Ala+OBzl S - - - BAl OBz - - - Arima et al., 2010
D-Leu-OBzl D-Leu+OBzl S - - - DLe OBz - - - Arima et al., 2010
D-Pro-OBzl D-Pro+OBzl S - - - DPr OBz - - - Arima et al., 2010
D-Val-OBzl D-Val+OBzl S - - - DVa OBz - - - Arima et al., 2010
Leu-NHNap Leu+NHNap S - - - Leu NAP - - - Nishimura et al., 2006
Phe-NHNap Phe+NHNap S - - - Phe NAP - - - Nishimura et al., 2006
Phe-NHPhNO2 Phe+NHPhNO2 S - - - Phe NAN - - - Arima et al., 2010
Pro-NHPhNO2 Pro+NHPhNO2 S - - - Pro NAN - - - Arima et al., 2010
Pro-OBzl Pro+OBzl S - - - Pro OBz - - - Arima et al., 2010
Pro-OMe Pro+OMe S - - - Pro OMe - - - Arima et al., 2010
Thr-OMe Thr+OMe S - - - Thr OMe - - - Arima et al., 2010
Tyr-Leu Tyr+Leu S - - - Tyr Leu - - - Nishimura et al., 2006
Tyr-NHNap Tyr+NHNap S - - - Tyr NAP - - - Nishimura et al., 2006
Tyr-Phe Tyr+Phe S - - - Tyr Phe - - - Nishimura et al., 2006
Val-OBzl Val+OBzl S - - - Val OBz - - - Arima et al., 2010