Substrates for peptidase S09.032: sphingopyxin I lasso peptide isopeptidase

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Asp11Ala sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Ala	Gln	Fage et al., 2016
Gln12Ala sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Asp	Ala	Fage et al., 2016
Glu14Ala sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Asp	Gln	Fage et al., 2016
Gly13Ala sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Asp	Gln	Fage et al., 2016
Leu17Ala sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Asp	Gln	Fage et al., 2016
Leu17Ala/Phe18Ala sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Asp	Gln	Fage et al., 2016
Phe18Ala sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Asp	Gln	Fage et al., 2016
Phe18Trp sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Asp	Gln	Fage et al., 2016
sphingopyxin I	Gly1+Asp9-peptide	P	-	-	-	Gly	Asp	Glu	Asp	Gln	Fage et al., 2016
Tyr16Trp sphingopyxin I	Gly1+Asp9-peptide	S	-	-	-	Gly	Asp	Glu	Asp	Gln	Fage et al., 2016