Substrates for peptidase S09.012: dipeptidyl-peptidase 5

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Ala-NHPhNO2 Ala-Ala+NHPhNO2 S - - Ala Ala NAN - - - Monod & Beauvais, 2004
Gly-Phe-NHPhNO2 Gly-Phe+NHPhNO2 S - - Gly Phe NAN - - - Beauvais et al., 1997
His-Ser-2-(4-methoxy)naphthylamide His-Ser+2-(4-methoxy)naphthylamide S - - His Ser MNA - - - Monod & Beauvais, 2004
Lys-Ala-NHMec Lys-Ala+NHMec S - - Lys Ala AMC - - - Monod et al., 2005
Lys-Ala-NHPhNO2 Lys-Ala+NHPhNO2 S - - Lys Ala NAN - - - Monod & Beauvais, 2004
NAPNE Ac-Phe+napthyl ester N - - Ac Phe ONe - - - Monod & Beauvais, 2004
Ser-Tyr-NHNap Ser-Tyr+NHNap S - - Ser Tyr NAP - - - Monod & Beauvais, 2004