Substrates for peptidase S09.005: dipeptidyl aminopeptidase A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Pro-NHPhNO2 Ala-Pro+NHPhNO2 S - - Ala Pro NAN - - - Misumi & Ikehara, 2004
alanyl bond Xaa-Ala+Xaa N - - NPe Ala Xaa - - - Misumi & Ikehara, 2004
alanyl bond Xaa-Ala+peptide N - - NPe Ala CPe - - - Misumi & Ikehara, 2004
alpha-1 mating factor precursor P01149 85-105 Glu-Ala+Glu-peptide P - - Glu Ala Glu Ala Trp His Misumi & Ikehara, 2004
alpha-1 mating factor precursor P01149 87-105 Glu-Ala-Glu-Ala+peptide P - - Glu Ala Trp His Trp Leu Misumi & Ikehara, 2004
alpha-1 mating factor precursor P01149 108-125 Glu-Ala-Glu-Ala+peptide P - - Glu Ala Trp His Trp Leu Misumi & Ikehara, 2004 17674
alpha-1 mating factor precursor P01149 106-125 Glu-Ala+Glu-peptide P - - Glu Ala Glu Ala Trp His Misumi & Ikehara, 2004 17672
Arg-Pro-NHPhNO2 Arg-Pro+NHPhNO2 S - - Arg Pro NAN - - - Misumi & Ikehara, 2004
Gly-Pro-NHMec Gly-Pro+NHMec S - - Gly Pro AMC - - - Cooper & Woods, 2009
Gly-Pro-NHPhNO2 Gly-Pro+NHPhNO2 S - - Gly Pro NAN - - - Misumi & Ikehara, 2004
kexin precursor P13134 20-814 Leu-Pro+peptide P - - Leu Pro Val Pro Ala Pro Fuller, 2004
kexin precursor P13134 20-814 Val-Pro+peptide P - - Val Pro Ala Pro Pro Met Fuller, 2004
prolyl bond Xaa-Pro+Xaa N - - NPe Pro Xaa - - - Misumi & Ikehara, 2004
prolyl bond Xaa-Pro+peptide N - - NPe Pro CPe - - - Misumi & Ikehara, 2004