Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Substrates for peptidase S08.109: KPC2-type peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg56+Asp-peptide P MS Phe Ser Lys Arg Asp Phe Asp Gly Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Lys85+Glu-peptide P MS Val Gln Lys Lys Glu Met Pro Gly Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Lys103+Ser-peptide P MS Asp Glu Lys Lys Ser Val Pro Gly Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg139+Glu-peptide P MS Met Asp Lys Arg Glu Ile Pro Gly Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg160+Ser-peptide P MS Phe Asp Lys Arg Ser Glu Val Pro Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg172+Asp-peptide P MS Phe Gly Lys Arg Asp Val Pro Gly Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg71+Gly-peptide P CS Phe Gly Lys Arg Gly Gly Val Trp Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg96+Ala-peptide P CS Phe Gly Lys Arg Ala Tyr Phe Asp Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg114+Ser-peptide P CS Phe Gly Lys Arg Ser Tyr Phe Asp Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg150+Asp-peptide P CS Phe Gly Lys Arg Asp Tyr Met Ala Husson et al., 2006
fMRFamide-like neuropeptide 18 Q9N4V0 22-208 peptide-Arg183+Ser-peptide P CS Phe Gly Lys Arg Ser Asp Leu Glu Husson et al., 2006
fMRFamide-like neuropeptides 1 P41855 1-175 peptide-Arg145+Ser-peptide P MS Phe Gly Lys Arg Ser Ala Asp Pro Husson et al., 2006
fMRFamide-like neuropeptides 1 P41855 1-175 peptide-Arg156+Ser-peptide P MS Arg Phe Gly Arg Ser Phe Asp Asn Husson et al., 2006
fMRFamide-like neuropeptides 1 P41855 1-175 peptide-Arg100+Ser-peptide P MS Arg Phe Gly Arg Ser Gln Pro Asn Husson et al., 2006
fMRFamide-like neuropeptides 1 P41855 1-175 peptide-Lys110+Ala-peptide P MS Arg Phe Gly Lys Ala Ser Gly Asp Husson et al., 2006
fMRFamide-like neuropeptides 1 P41855 1-175 peptide-Arg122+Ser-peptide P MS Arg Phe Gly Arg Ser Asp Pro Asn Husson et al., 2006
fMRFamide-like neuropeptides 1 P41855 1-175 peptide-Lys132+Ala-peptide P MS Arg Phe Gly Lys Ala Ala Ala Asp Husson et al., 2006
fMRFamide-like neuropeptides 11 Q21156 23-110 peptide-Arg31+Ala-peptide P MS Ala Glu Lys Arg Ala Met Arg Asn Husson et al., 2006
fMRFamide-like neuropeptides 11 Q21156 23-110 peptide-Arg42+Ala-peptide P MS Arg Phe Gly Arg Ala Ser Gly Gly Husson et al., 2006
fMRFamide-like neuropeptides 11 Q21156 23-110 peptide-Arg57+Ser-peptide P CS Phe Gly Lys Arg Ser Pro Leu Asp Husson et al., 2006
fMRFamide-like neuropeptides 11 Q21156 23-110 peptide-Arg75+Asn-peptide P MS Gln Gly Lys Arg Asn Gly Ala Pro Husson et al., 2006
fMRFamide-like neuropeptides 11 Q21156 23-110 peptide-Arg87+Ser-peptide P CS Arg Phe Gly Arg Ser Gly Gln Leu Husson et al., 2006
fMRFamide-like neuropeptides 13 O44185 18-160 peptide-Arg75+Ala-peptide P MS Arg Phe Gly Arg Ala Pro Glu Ala Husson et al., 2006
fMRFamide-like neuropeptides 13 O44185 18-160 peptide-Arg88+Ala-peptide P CS Phe Gly Lys Arg Ala Ala Asp Gly Husson et al., 2006
fMRFamide-like neuropeptides 13 O44185 18-160 peptide-Arg113+Ala-peptide P MS Phe Gly Lys Arg Ala Ser Pro Ser Husson et al., 2006
fMRFamide-like neuropeptides 13 O44185 18-160 peptide-Arg125+Ser-peptide P MS Arg Phe Gly Arg Ser Pro Ser Ala Husson et al., 2006
fMRFamide-like neuropeptides 13 O44185 18-160 peptide-Arg100+Ala-peptide P MS Arg Phe Gly Arg Ala Pro Glu Ala Husson et al., 2006
fMRFamide-like neuropeptides 13 O44185 18-160 peptide-Arg137+Ser-peptide P CS Arg Phe Gly Arg Ser Ala Ala Ala Husson et al., 2006
fMRFamide-like neuropeptides 14 Q9XWV7 21-143 peptide-Arg113+Lys-peptide P MS Phe Gly Lys Arg Lys His Glu Tyr Husson et al., 2006
fMRFamide-like neuropeptides 14 Q9XWV7 21-143 peptide-Arg123+Lys-peptide P CS Phe Gly Lys Arg Lys His Glu Tyr Husson et al., 2006
fMRFamide-like neuropeptides 14 Q9XWV7 21-143 peptide-Arg103+Lys-peptide P MS Met Glu Lys Arg Lys His Glu Tyr Husson et al., 2006
fMRFamide-like neuropeptides 14 Q9XWV7 21-143 peptide-Arg133+Lys-peptide P MS Phe Gly Lys Arg Lys His Glu Tyr Husson et al., 2006
fMRFamide-like neuropeptides 19 Q9XVX1 21-89 peptide-Arg69+Trp-peptide P MS Met Glu Lys Arg Trp Ala Asn Gln Husson et al., 2006
fMRFamide-like neuropeptides 19 Q9XVX1 21-89 peptide-Arg79+Ala-peptide P MS Phe Gly Lys Arg Ala Ser Trp Ala Husson et al., 2006
fMRFamide-like neuropeptides 24 O17058 26-69 peptide-Arg53+Val-peptide P MS Pro His Lys Arg Val Pro Ser Ala Husson et al., 2006
fMRFamide-like neuropeptides 24 O17058 26-69 peptide-Arg67+Ser-Ile P CS Phe Gly Lys Arg Ser Ile - - Husson et al., 2006
fMRFamide-like neuropeptides 26 Q8MPY9 20-84 peptide-Arg40+Asn-peptide P MS Leu Thr Lys Arg Asn Tyr Tyr Glu Husson et al., 2006
fMRFamide-like neuropeptides 26 Q8MPY9 20-84 peptide-Arg50+Glu-peptide P MS Pro Tyr Lys Arg Glu Phe Asn Ala Husson et al., 2006
fMRFamide-like neuropeptides 26 Q8MPY9 20-84 peptide-Arg64+Gly-peptide P MS Phe Gly Lys Arg Gly Gly Ala Gly Husson et al., 2006
fMRFamide-like neuropeptides 27 Q18184 24-89 peptide-Arg37+Glu-peptide P CS Met Glu Arg Arg Glu Ala Ser Ala Husson et al., 2006
fMRFamide-like neuropeptides 3 Q23212 23-184 peptide-Arg114+Ala-peptide P MS Phe Gly Lys Arg Ala Ser Glu Asp Husson et al., 2006
fMRFamide-like neuropeptides 3 Q23212 23-184 peptide-Arg129+Glu-peptide P CS Phe Gly Lys Arg Glu Asp Gly Asn Husson et al., 2006
fMRFamide-like neuropeptides 3 Q23212 23-184 peptide-Arg85+Ser-peptide P MS Phe Gly Lys Arg Ser Ala Glu Pro Husson et al., 2006
fMRFamide-like neuropeptides 3 Q23212 23-184 peptide-Arg98+Asn-peptide P MS Phe Gly Lys Arg Asn Pro Glu Asn Husson et al., 2006
fMRFamide-like neuropeptides 3 Q23212 23-184 peptide-Arg158+Ser-peptide P MS Phe Gly Lys Arg Ser Ala Asp Asp Husson et al., 2006
fMRFamide-like neuropeptides 3 Q23212 23-184 peptide-Arg174+Asn-peptide P CS Phe Gly Lys Arg Asn Pro Leu Gly Husson et al., 2006
fMRFamide-like neuropeptides 9 Q18502 20-102 peptide-Arg65+Lys-peptide P MS Met Glu Lys Arg Lys Pro Ser Phe Husson et al., 2006
fMRFamide-like neuropeptides 9 Q18502 20-102 peptide-Arg75+Ser-peptide P CS Phe Gly Lys Arg Ser Gly Tyr Pro Husson et al., 2006
fMRFamide-like peptide 2a G5EFN6 1-106 peptide-Arg85+Ser-peptide P MS Phe Gly Lys Arg Ser Pro Arg Glu Husson et al., 2006
fMRFamide-like peptide 2a G5EFN6 1-106 peptide-Arg96+Phe-peptide P CS Phe Gly Lys Arg Phe Asn Pro Leu Husson et al., 2006
fMRFamide-like peptide 7 G5EEC2 1-177 peptide-Arg78+Ser-peptide P MS Phe Gly Lys Arg Ser Pro Met Gln Husson et al., 2006
fMRFamide-like peptide 7 G5EEC2 1-177 peptide-Arg92+Ser-peptide P CS Phe Gly Lys Arg Ser Pro Met Gln Husson et al., 2006
fMRFamide-like peptide 7 G5EEC2 1-177 peptide-Arg146+Thr-peptide P MS Leu Gly Lys Arg Thr Pro Met Gln Husson et al., 2006
fMRFamide-like peptide 7 G5EEC2 1-177 peptide-Arg160+Ser-peptide P CS Phe Gly Lys Arg Ser Met Glu Phe Husson et al., 2006
fMRFamide-like peptide 7 G5EEC2 1-177 peptide-Arg64+Ser-peptide P MS Arg Phe Gly Arg Ser Pro Met Gln Husson et al., 2006
neuropeptide-like peptide 11 Q09367 1-134 peptide-Arg58+His-peptide P MS Gln Ser Lys Arg His Ile Ser Pro Husson et al., 2006
neuropeptide-like peptide 11 Q09367 1-134 peptide-Arg82+Ser-peptide P MS Ile Gly Lys Arg Ser Ala Pro Met Husson et al., 2006
neuropeptide-like peptide 11 Q09367 1-134 peptide-Lys106+Lys-peptide P CS Ala Gly Lys Lys Lys Arg Ser Pro Husson et al., 2006
neuropeptide-like peptide 11 Q09367 1-134 peptide-Arg108+Ser-peptide P MS Lys Lys Lys Arg Ser Pro Ala Ile Husson et al., 2006
neuropeptide-like protein 1 Q11088 20-176 peptide-Arg25+Met-peptide P MS Leu Pro Lys Arg Met Asp Ala Asn Husson et al., 2006
neuropeptide-like protein 1 Q11088 20-176 peptide-Arg38+Ser-peptide P CS Phe Gly Lys Arg Ser Val Ser Asn Husson et al., 2006
neuropeptide-like protein 1 Q11088 20-176 peptide-Arg142+Val-peptide P MS Phe Gly Lys Arg Val Asn Leu Asp Husson et al., 2006
neuropeptide-like protein 1 Q11088 20-176 peptide-Arg157+Ser-peptide P CS Phe Gly Lys Arg Ser Thr Val Gly Husson et al., 2006
neuropeptide-like protein 1 Q11088 20-176 peptide-Arg48+Met-peptide P MS Glu Ala Lys Arg Met Asp Pro Asn Husson et al., 2006
neuropeptide-like protein 1 Q11088 20-176 peptide-Arg61+Ser-peptide P CS Phe Gly Lys Arg Ser Ala Glu Gln Husson et al., 2006
neuropeptide-like protein 1 Q11088 20-176 peptide-Arg91+Met-peptide P MS Glu Met Lys Arg Met Asp Ala Asn Husson et al., 2006
neuropeptide-like protein 1 Q11088 20-176 peptide-Arg104+Ser-peptide P CS Phe Gly Lys Arg Ser Asp Ala His Husson et al., 2006
neuropeptide-like protein protein 12 O01970 1-80 peptide-Arg32+Asp-peptide P MS Arg Gln Asp Arg Asp Tyr Arg Pro Husson et al., 2006
neuropeptide-like protein protein 12 O01970 1-80 peptide-Arg42+Asp-peptide P MS Phe Gly Lys Arg Asp Gly Tyr Arg Husson et al., 2006
neuropeptide-like protein protein 12 O01970 1-80 peptide-Arg53+Asp-peptide P CS Phe Gly Lys Arg Asp Tyr Arg Pro Husson et al., 2006
neuropeptide-like protein protein 13 O44540 1-137 peptide-Arg31+Asn-peptide P MS Ser Ala Lys Arg Asn Asp Phe Ser Husson et al., 2006
neuropeptide-like protein protein 13 O44540 1-137 peptide-Arg44+Ser-peptide P MS Phe Gly Lys Arg Ser Gly Asn Thr Husson et al., 2006
neuropeptide-like protein protein 13 O44540 1-137 peptide-Arg62+Gln-peptide P CS Phe Gly Lys Arg Gln Pro Ser Tyr Husson et al., 2006
neuropeptide-like protein protein 13 O44540 1-137 peptide-Arg76+Ser-peptide P MS Phe Gly Lys Arg Ser Ala Pro Ser Husson et al., 2006
neuropeptide-like protein protein 13 O44540 1-137 peptide-Arg92+Ser-peptide P MS Phe Gly Lys Arg Ser Ser Ser Met Husson et al., 2006
neuropeptide-like protein protein 13 O44540 1-137 peptide-Arg107+Ser-peptide P MS Phe Gly Lys Arg Ser Pro Val Asp Husson et al., 2006
neuropeptide-like protein protein 13 O44540 1-137 peptide-Arg122+Ala-peptide P MS Phe Gly Lys Arg Ala Glu Asp Tyr Husson et al., 2006
neuropeptide-like protein protein 16 Q22442 1-326 peptide-Arg160+Ser-peptide P MS His Gln Lys Arg Ser Val Asp Glu Husson et al., 2006
neuropeptide-like protein protein 16 Q22442 1-326 peptide-Arg182+Ser-peptide P CS His Gln Lys Arg Ser Glu His Val Husson et al., 2006
neuropeptide-like protein protein 16 Q22442 1-326 peptide-Lys171+Asn-peptide P MS His Gln Lys Lys Asn Ala Glu Asp Husson et al., 2006
neuropeptide-like protein protein 20, confirmed by transcript evidence Q94233 1-99 peptide-Arg66+Ser-peptide P MS Ile Glu Ala Arg Ser Gly Pro Gln Husson et al., 2006
neuropeptide-like protein protein 20, confirmed by transcript evidence Q94233 1-99 peptide-Arg84+Arg-peptide P CS Phe Ala Lys Arg Arg Ala Pro Lys Husson et al., 2006
neuropeptide-like protein protein 7 Q19569 1-121 peptide-Arg83+Met-peptide P MS Phe Gly Lys Arg Met Ile Leu Pro Husson et al., 2006
neuropeptide-like protein protein 7 Q19569 1-121 peptide-Arg101+Gly-peptide P CS Tyr Asp Lys Arg Gly Ser Asp Ile Husson et al., 2006
neuropeptide-like protein protein 7 Q19569 1-121 peptide-Arg65+Ser-peptide P MS Ile Gln Arg Arg Ser Met Asp Asp Husson et al., 2006
pigment dispersing factor 2 G5EGC3 1-89 peptide-Arg65+Asn-peptide P MS Ile Asn Lys Arg Asn Asn Ala Glu Husson et al., 2006
protein C01A2.7, confirmed by transcript evidence Q8T3G1 20-101 peptide-Arg87+Ser-peptide P MS Leu Tyr Lys Arg Ser Pro Ala Gln Husson et al., 2006
protein C01A2.7, confirmed by transcript evidence Q8T3G1 20-101 peptide-Arg24+Val-peptide P MS Ser Asp Asp Arg Val Leu Gly Trp Husson et al., 2006
protein C01A2.7, confirmed by transcript evidence Q8T3G1 20-101 peptide-Arg38+Ser-peptide P CS Trp Gly Lys Arg Ser Val Gln Glu Husson et al., 2006
protein C04H5.8, confirmed by transcript evidence Q7YX92 1-71 peptide-Arg39+Ser-peptide P CS Arg Leu Ile Arg Ser Asp Pro Ser Husson et al., 2006
protein C33A12.2, confirmed by transcript evidence Q18356 24-71 peptide-Arg42+Ala-peptide P CS Arg Phe Arg Arg Ala Arg Met Met Husson et al., 2006
protein D2005.2, confirmed by transcript evidence Q93409 27-172 peptide-Arg47+Ala-peptide P MS Leu Val Lys Arg Ala Phe Asp Arg Husson et al., 2006
protein D2005.2, confirmed by transcript evidence Q93409 27-172 peptide-Arg64+Phe-peptide P CS Gly Ala Lys Arg Phe Asp Arg Tyr Husson et al., 2006
protein D2005.2, confirmed by transcript evidence Q93409 27-172 peptide-Lys99+Ala-peptide P MS Pro Thr Lys Lys Ala Phe Asp Arg Husson et al., 2006
protein D2005.2, confirmed by transcript evidence Q93409 27-172 peptide-Arg114+Lys-peptide P CS Gly Ala Lys Arg Lys Arg Ser Phe Husson et al., 2006
protein D2005.2, confirmed by transcript evidence Q93409 27-172 peptide-Arg116+Ser-peptide P MS Lys Arg Lys Arg Ser Phe Asp Arg Husson et al., 2006
protein D2005.2, confirmed by transcript evidence Q93409 27-172 peptide-Arg131+Ser-peptide P CS Leu Met Lys Arg Ser Ala Pro Glu Husson et al., 2006
protein F33A8.2, confirmed by transcript evidence O62211 1-99 peptide-Arg70+Ser-peptide P MS Phe Ala Lys Arg Ser Pro Tyr Arg Husson et al., 2006
protein F33A8.2, confirmed by transcript evidence O62211 1-99 peptide-Arg81+Ala-peptide P CS Phe Ala Lys Arg Ala Ser Pro Tyr Husson et al., 2006
protein F39H2.1, confirmed by transcript evidence Q93702 1-93 peptide-Arg46+Ser-peptide P MS Gln Val Lys Arg Ser Pro Ser Ala Husson et al., 2006
protein F39H2.1, confirmed by transcript evidence Q93702 1-93 peptide-Met53+Arg-peptide P CS Ala Lys Trp Met Arg Phe Gly Lys Husson et al., 2006
protein K04H4.7, confirmed by transcript evidence Q6LAC9 1-96 peptide-Lys85+Ala-peptide P MS Pro Ile Lys Lys Ala Ser Tyr Asp Husson et al., 2006
protein W07E11.4, partially confirmed by transcript evidence Q7YWT6 24-71 peptide-Arg35+Gly-peptide P CS Phe Gly Lys Arg Gly Gly Asn Ser Husson et al., 2006
protein Y43F8C.1, partially confirmed by transcript evidence Q9XWP3 21-87 peptide-Arg41+Gly-peptide P MS Gly Tyr Gly Arg Gly Gly Gly Tyr Husson et al., 2006
protein Y43F8C.2, confirmed by transcript evidence Q9XWN4 1-90 peptide-Arg46+Gly-peptide P MS Asn Gly Asn Arg Gly Gly Phe Gly Husson et al., 2006
protein Y43F8C.2, confirmed by transcript evidence Q9XWN4 1-90 peptide-Arg58+Gly-peptide P CS Phe Gly Gly Arg Gly Gly Asn Gln Husson et al., 2006
protein Y47D3B.2a, confirmed by transcript evidence Q9XX02 1-164 peptide-Arg60+Gly-peptide P MS Asp Tyr Lys Arg Gly Gly Ala Arg Husson et al., 2006
protein Y47D3B.2a, confirmed by transcript evidence Q9XX02 1-164 peptide-Arg71+Gly-peptide P MS Asp Glu Lys Arg Gly Gly Ala Arg Husson et al., 2006
protein Y47D3B.2a, confirmed by transcript evidence Q9XX02 1-164 peptide-Arg97+Gly-peptide P CS Asp Glu Lys Arg Gly Gly Ala Arg Husson et al., 2006
protein Y47D3B.2a, confirmed by transcript evidence Q9XX02 1-164 peptide-Arg83+Gly-peptide P MS Glu Met Lys Arg Gly Gly Ala Arg Husson et al., 2006
protein ZK525.1, confirmed by transcript evidence O46023 1-87 peptide-Arg58+Arg-peptide P MS Phe Gly Lys Arg Arg Gly Pro Ser Husson et al., 2006
protein ZK525.1, confirmed by transcript evidence O46023 1-87 peptide-Arg70+Ser-peptide P CS Phe Gly Lys Arg Ser Ser Phe His Husson et al., 2006
protein ZK525.1, confirmed by transcript evidence O46023 1-87 peptide-Lys46+Gly-peptide P MS Tyr Val Lys Lys Gly Gly Pro Gln Husson et al., 2006
putative uncharacterized protein Q9N4D8 1-123 peptide-Lys50+Glu-peptide P MS Val Lys Gln Lys Glu Gln Pro Ala Husson et al., 2006
putative uncharacterized protein Q9N4D8 1-123 peptide-Arg67+Met-peptide P CS Pro Gln Lys Arg Met Val Ala Trp Husson et al., 2006

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use