Substrates for peptidase S06.001: IgA1-specific serine peptidase (Neisseria-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
consensus prolyl bond peptide-Pro+Xaa-Pro-peptide N - - NPe Pro Xaa Pro CPe - Poulsen & Kilian, 2004
immunoglobulin IgA1 peptide-Pro237+Ser-peptide P Pro Pro Thr Pro Ser Pro Pro Ser Poulsen & Kilian, 2004
type 2 IgA1 protease precursor P09790 28-1532 peptide-Pro1018+Ser-peptide P Val Ala Pro Pro Ser Pro Gln Ala Poulsen & Kilian, 2004 17461
type 2 IgA1 protease precursor P09790 28-1532 peptide-Pro1121+Ala-peptide P Pro Arg Pro Pro Ala Pro Val Phe Poulsen & Kilian, 2004 17459
type 2 IgA1 protease precursor P09790 28-1532 peptide-Pro986+Ser-peptide N Lys Pro Ala Pro Ser Pro Ala Ala 17457
type 2 IgA1 protease precursor ({Neisseria gonorrhoeae}) peptide-Val-Lys-Pro+Ser-Pro-Ala-Ala-Asn-peptide N NPe Val Lys Pro Ser Pro Ala Ala Poulsen & Kilian, 2004