Substrates for peptidase S01.494: Htra2 peptidase (Mycobacterium-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
probable serine protease PEPD	O53896	125-464	peptide-Ala148+Ala-peptide	P	Ser	Ile	Pro	Ala	Ala	Asn	Met	Pro	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val159+Ala-peptide	N	Val	Glu	Gln	Val	Ala	Ala	Lys	Val	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Thr172+Asp-peptide	N	Met	Leu	Glu	Thr	Asp	Leu	Gly	Arg	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Ser182+Gly-peptide	N	Glu	Glu	Gly	Ser	Gly	Ile	Ile	Leu	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Ala188+Glu-peptide	N	Ile	Leu	Ser	Ala	Glu	Gly	Leu	Ile	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Ala201+Ala-peptide	N	Val	Ile	Ala	Ala	Ala	Ala	Lys	Pro	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val216+Thr-peptide	N	Lys	Thr	Thr	Val	Thr	Phe	Ser	Asp	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Thr217+Phe-peptide	N	Thr	Thr	Val	Thr	Phe	Ser	Asp	Gly	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Ser219+Asp-peptide	N	Val	Thr	Phe	Ser	Asp	Gly	Arg	Thr	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Thr227+Val-peptide	N	Ala	Pro	Phe	Thr	Val	Val	Gly	Ala	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val228+Val-peptide	N	Pro	Phe	Thr	Val	Val	Gly	Ala	Asp	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val229+Gly-peptide	N	Phe	Thr	Val	Val	Gly	Ala	Asp	Pro	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val240+Arg-peptide	N	Ile	Ala	Val	Val	Arg	Val	Gln	Gly	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Ile251+Ser-peptide	N	Leu	Thr	Pro	Ile	Ser	Leu	Gly	Ser	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Ser257+Asp-peptide	N	Gly	Ser	Ser	Ser	Asp	Leu	Arg	Val	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val265+Leu-peptide	N	Gly	Gln	Pro	Val	Leu	Ala	Ile	Gly	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Ile282+Val-peptide	N	Thr	Thr	Gly	Ile	Val	Ser	Ala	Leu	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val283+Ser-peptide	N	Thr	Gly	Ile	Val	Ser	Ala	Leu	Asn	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val290+Ser-peptide	N	Asn	Arg	Pro	Val	Ser	Thr	Thr	Gly	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Thr301+Val-peptide	N	Asn	Gln	Asn	Thr	Val	Leu	Asp	Ala	MohamedMohaideen et al., 2008
probable serine protease PEPD	O53896	125-464	peptide-Val358+Asp-peptide	N	Ala	Ile	Pro	Val	Asp	Gln	Ala	Lys	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Ala361+Lys-peptide	N	Val	Asp	Gln	Ala	Lys	Arg	Ile	Ala	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Ile364+Ala-peptide	N	Ala	Lys	Arg	Ile	Ala	Asp	Glu	Leu	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Ile369+Ser-peptide	N	Asp	Glu	Leu	Ile	Ser	Thr	Gly	Lys	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val381+Gln-peptide	N	Ser	Leu	Gly	Val	Gln	Val	Thr	Asn	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val383+Thr-peptide	N	Gly	Val	Gln	Val	Thr	Asn	Asp	Lys	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val395+Glu-peptide	N	Ala	Lys	Ile	Val	Glu	Val	Val	Ala	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val412+Val-peptide	N	Pro	Lys	Gly	Val	Val	Val	Thr	Lys	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val414+Thr-peptide	N	Gly	Val	Val	Val	Thr	Lys	Val	Asp	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Ile422+Asn-peptide	N	Asp	Arg	Pro	Ile	Asn	Ser	Ala	Asp	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Ala430+Ala-peptide	N	Ala	Leu	Val	Ala	Ala	Val	Arg	Ser	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Ala431+Val-peptide	N	Leu	Val	Ala	Ala	Val	Arg	Ser	Lys	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val432+Arg-peptide	N	Val	Ala	Ala	Val	Arg	Ser	Lys	Ala	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val441+Ala-peptide	N	Gly	Ala	Thr	Val	Ala	Leu	Thr	Phe	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Ala442+Leu-peptide	N	Ala	Thr	Val	Ala	Leu	Thr	Phe	Gln	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Leu443+Thr-peptide	N	Thr	Val	Ala	Leu	Thr	Phe	Gln	Asp	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val455+Gln-peptide	N	Ser	Arg	Thr	Val	Gln	Val	Thr	Leu	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Val457+Thr-peptide	N	Thr	Val	Gln	Val	Thr	Leu	Gly	Lys	MohamedMohaideen et al., 2008
probable serine protease PepD	O53896	125-464	peptide-Ala377+Ser-peptide	P	Ala	Ser	His	Ala	Ser	Leu	Gly	Val	MohamedMohaideen et al., 2008