Substrates for peptidase S01.237: neurotrypsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Agrin(alpha)	P25304-1	51-1752	Peptide-Arg995+Ala-Peptide	P	NT	Pro	Ile	Glu	Arg	Ala	Ser	Cys	Tyr	Reif et al., 2007
Agrin(beta)	P25304-1	1528-1959	Peptide-Lys1754+Ser-Peptide	P	NT	Leu	Val	Glu	Lys	Ser	Val	Gly	Asp	Reif et al., 2007
mini-agrin	Q5EBX5	1-961	peptide-Lys775+Ser-peptide	P	NT	Ile	Val	Glu	Lys	Ser	Val	Gly	Asp	Patel et al., 2021