Substrates for peptidase S01.137: granzyme C

Summary Gene structure Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
60S ribosomal protein L34	Q9D1R9	2-117	peptide-Leu33+Tyr-peptide	P	MS	Ile	Val	Tyr	Leu	Tyr	Thr	Lys	Lys	Kaiserman et al., 2009
Acidic leucine-rich nuclear phosphoprotein 32 family member A	O35381	1-247	peptide-Asn213+Asp-peptide	P	MS	Glu	Gly	Tyr	Asn	Asp	Gly	Glu	Val	Kaiserman et al., 2009
ATP-dependent RNA helicase DDX42	Q810A7	1-929	peptide-Phe119+Met-peptide	P	MS	Leu	Glu	Ala	Phe	Met	Ala	Glu	Val	Kaiserman et al., 2009
ATP-dependent RNA helicase DDX42	Q810A7	1-929	peptide-Met120+Ala-peptide	P	MS	Glu	Ala	Phe	Met	Ala	Glu	Val	Glu	Kaiserman et al., 2009
Cell division cycle 5-like protein	Q6A068	1-802	peptide-Tyr225+Asp-peptide	P	MS	Leu	Gly	Phe	Tyr	Asp	Thr	Ser	Glu	Kaiserman et al., 2009
Centrosomal protein of 170 kDa	Q6A065	1-1588	peptide-Leu603+Ser-peptide	P	MS	Leu	Met	Glu	Leu	Ser	Ala	Thr	Val	Kaiserman et al., 2009
DNA replication licensing factor MCM5	P49718	1-733	peptide-Tyr11+Ser-peptide	P	MS	Gly	Ile	Phe	Tyr	Ser	Asp	Ser	Phe	Kaiserman et al., 2009
DNA-binding protein Ikaros	Q03267	1-517	peptide-Met73+Asn-peptide	P	MS	Ala	Cys	Glu	Met	Asn	Gly	Glu	Glu	Kaiserman et al., 2009
Double-stranded RNA-binding protein Staufen homolog 1	Q9Z108	1-487	peptide-Phe296+Glu-peptide	P	MS	Val	Thr	Phe	Phe	Glu	Pro	Ser	Pro	Kaiserman et al., 2009
Flap endonuclease 1	P39749	1-378	peptide-Met308+Cys-peptide	P	MS	Val	Lys	Phe	Met	Cys	Gly	Glu	Lys	Kaiserman et al., 2009
GRB2-related adaptor protein 2	O89100	1-322	peptide-Met10+Ala-peptide	P	MS	Phe	Asp	Phe	Met	Ala	Ser	Gly	Glu	Kaiserman et al., 2009
Hematological and neurological expressed 1 protein	P97825	2-154	peptide-Asn143+Pro-peptide	P	MS	Ser	Arg	Arg	Asn	Pro	Pro	Gly	Gly	Kaiserman et al., 2009
Heterogeneous nuclear ribonucleoprotein U-like protein 2	Q00PI9	1-745	peptide-Tyr602+Met-peptide	P	MS	Lys	Cys	Asp	Tyr	Met	Asp	Glu	Val	Kaiserman et al., 2009
Nucleolin	P09405	2-707	peptide-Phe438+Lys-peptide	P	MS	Tyr	Ile	Glu	Phe	Lys	Ser	Glu	Ala	Kaiserman et al., 2009
Pescadillo homolog	Q9EQ61	1-584	peptide-Met508+Ala-peptide	P	MS	Pro	Gln	Val	Met	Ala	Gly	Thr	Val	Kaiserman et al., 2009
Probable rRNA-processing protein EBP2	Q9D903	1-306	peptide-Leu213+Glu-peptide	P	MS	Leu	Asp	Phe	Leu	Glu	Gly	Asp	Gln	Kaiserman et al., 2009
Protein LTV1 homolog	Q6NSQ7	1-470	peptide-Phe113+Ala-peptide	P	MS	Ser	Ser	Val	Phe	Ala	Ser	Glu	Phe	Kaiserman et al., 2009
RNA polymerase-associated protein CTR9 homolog	Q62018	1-1173	peptide-Phe891+Thr-peptide	P	MS	Ile	Leu	Met	Phe	Thr	Gly	Glu	Thr	Kaiserman et al., 2009
RNA-binding protein 5	Q91YE7	1-815	peptide-Tyr620+Ser-peptide	P	MS	Val	Ala	Ala	Tyr	Ser	Gly	Asp	Ser	Kaiserman et al., 2009