Substrates for peptidase N10.004: intein-containing translation initiation factor IF-2 precursor

Summary Alignment Tree Sequences Sequence features Distribution Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'
dNA polymerase	O33845	1-1829	peptide-Asp1441+Ser-peptide	N	CS	Leu	Tyr	Ala	Asp	Ser	Val	Thr	Gly
dNA polymerase	O33845	1-1829	peptide-Asn1598+Thr-peptide	N	CS	Leu	Val	His	Asn	Thr	Asp	Gly	Phe
dNA replication licensing factor, MCM2/3/5 family	Q5JIT1	1-1157	peptide-Leu362+Cys-peptide	N	CS	Ala	Ala	Gly	Leu	Cys	Val	Ala	Pro
dNA replication licensing factor, MCM2/3/5 family	Q5JIT1	1-1157	peptide-Asn502+Thr-peptide	N	CS	Val	Val	His	Asn	Thr	Ala	Ala	Ala
dNA replication licensing factor, Mcm2/Cdc19 ATPase, containing 2 inteins	C5A2A7	1-1171	peptide-Ala390+Cys-peptide	N	CS	Gly	Gly	Phe	Ala	Cys	Leu	His	Pro
dNA replication licensing factor, Mcm2/Cdc19 ATPase, containing 2 inteins	C5A2A7	1-1171	peptide-Asn547+Cys-peptide	N	CS	Ile	Val	His	Asn	Cys	Ile	Asp	Glu
DNA topoisomerase 1	O73954	1-1060	peptide-Phe314+Cys-peptide	N	CS	Glu	Lys	Gly	Phe	Cys	Leu	His	Pro
DNA topoisomerase 1	O73954	1-1060	peptide-Asn687+Cys-peptide	N	CS	Ala	Val	His	Asn	Cys	Ser	Tyr	Pro
dNA topoisomerase I	Q5JE24	1-1229	peptide-Tyr315+Cys-peptide	N	CS	Glu	Lys	Gly	Tyr	Cys	Leu	His	Pro
dNA topoisomerase I	Q5JE24	1-1229	peptide-Asn826+Cys-peptide	N	CS	Val	Val	His	Asn	Cys	Ser	Tyr	Pro
dNA topoisomerase I	D3S8D0	1-973	peptide-Leu308+Cys-peptide	N	CS	Glu	Lys	Gly	Leu	Cys	Leu	His	Pro
dNA topoisomerase I	D3S8D0	1-973	peptide-Asn525+Cys-peptide	N	CS	Val	Val	His	Asn	Cys	Ser	Tyr	Pro
DNA topoisomerase I	C6A350	1-1228	peptide-Tyr315+Cys-peptide	N	CS	Glu	Lys	Gly	Tyr	Cys	Leu	His	Pro
DNA topoisomerase I	C6A350	1-1228	peptide-Asn826+Cys-peptide	N	CS	Val	Val	His	Asn	Cys	Ser	Tyr	Pro
dNA topoisomerase I	D5VT99	1-776	peptide-Leu304+Cys-peptide	N	CS	Glu	Lys	Gly	Leu	Cys	Leu	His	Pro
dNA topoisomerase I	D5VT99	1-776	peptide-Asn461+Cys-peptide	N	CS	Val	Val	His	Asn	Cys	Ser	Tyr	Pro
mCM family protein	D2RHT0	1-1707	peptide-Leu352+Cys-peptide	N	CS	Gly	Ala	Gly	Leu	Cys	Val	Ala	Pro
mCM family protein	D2RHT0	1-1707	peptide-Asn900+Thr-peptide	N	CS	Val	Val	His	Asn	Thr	Val	Thr	Ala
mCM inteins containing helicase, minichromosome maintenance protein	Q9UYR7	1-1112	peptide-Leu525+Cys-peptide	N	CS	Ala	Ala	Gly	Leu	Cys	Val	Ala	Pro
mCM inteins containing helicase, minichromosome maintenance protein	Q9UYR7	1-1112	peptide-Asn793+Thr-peptide	N	CS	Val	Val	His	Asn	Thr	Ala	Ala	Val
probable translation initiation factor IF-2	Q8U1R8	1-984	peptide-Lys19+Cys-peptide	N	CS	Asp	His	Gly	Lys	Cys	Leu	Leu	Pro
probable translation initiation factor IF-2	Q8U1R8	1-984	peptide-Asn406+Thr-peptide	N	CS	Leu	Val	His	Asn	Thr	Thr	Leu	Leu
probable translation initiation factor IF-2	Q57710	1-1155	peptide-Lys30+Cys-peptide	N	CS	Asp	His	Gly	Lys	Cys	Leu	Met	Pro
probable translation initiation factor IF-2	Q57710	1-1155	peptide-Asn576+Thr-peptide	N	CS	Val	Val	His	Asn	Thr	Thr	Leu	Leu
probable translation initiation factor IF-2	Q9UZK7	1-992	peptide-Lys20+Cys-peptide	N	CS	Asp	His	Gly	Lys	Cys	Leu	Leu	Pro
probable translation initiation factor IF-2	Q9UZK7	1-992	peptide-Asn414+Thr-peptide	N	CS	Leu	Val	His	Asn	Thr	Thr	Leu	Leu
probable translation initiation factor IF-2	Q5JGR9	1-1144	peptide-Lys20+Cys-peptide	N	CS	Asp	His	Gly	Lys	Cys	Leu	Leu	Pro
probable translation initiation factor IF-2	Q5JGR9	1-1144	peptide-Asn566+Thr-peptide	N	CS	Leu	Val	His	Asn	Thr	Thr	Leu	Leu
probable translation initiation factor IF-2	D5VR05	1-859	peptide-Lys26+Cys-peptide	N	CS	Asp	His	Gly	Lys	Cys	Leu	Ser	Pro
probable translation initiation factor IF-2	D5VR05	1-859	peptide-Asn280+Thr-peptide	N	CS	Leu	Val	His	Asn	Thr	Thr	Leu	Leu
probable translation initiation factor IF-2	O58822	1-1044	peptide-Lys22+Cys-peptide	N	CS	Asp	His	Gly	Lys	Cys	Leu	Leu	Pro
probable translation initiation factor IF-2	O58822	1-1044	peptide-Asn466+Thr-peptide	N	CS	Leu	Val	His	Asn	Thr	Thr	Leu	Leu
probable translation initiation factor IF-2	D3S813	1-1155	peptide-Lys30+Cys-peptide	N	CS	Asp	His	Gly	Lys	Cys	Leu	Met	Pro
probable translation initiation factor IF-2	D3S813	1-1155	peptide-Asn576+Thr-peptide	N	CS	Ile	Val	His	Asn	Thr	Thr	Leu	Leu
probable translation initiation factor IF-2	D2RGZ0	1-1144	peptide-Lys23+Cys-peptide	N	CS	Asp	His	Gly	Lys	Cys	Leu	Thr	Pro
probable translation initiation factor IF-2	D2RGZ0	1-1144	peptide-Asn574+Thr-peptide	N	CS	Ile	Val	His	Asn	Thr	Thr	Leu	Leu
protein splicing site	Q115K1	1-1531	peptide-Lys610+Cys-peptide	N	CS	Gly	Leu	Gly	Lys	Cys	Val	Leu	His
protein splicing site	Q115K1	1-1531	peptide-Asn1079+Thr-peptide	N	CS	Ile	Cys	His	Asn	Thr	Ile	Gln	Thr
reverse gyrase	Q6F598	1-1711	peptide-Leu960+Cys-peptide	N	CS	Glu	Ala	Gly	Leu	Cys	Val	Thr	Pro
reverse gyrase	Q6F598	1-1711	peptide-Asn1449+Cys-peptide	N	CS	Val	Ser	His	Asn	Cys	Thr	Tyr	His
reverse gyrase	C9RHR6	1-1443	peptide-Leu867+Cys-peptide	N	CS	Glu	Leu	Gly	Leu	Cys	Leu	Thr	Pro
reverse gyrase	C9RHR6	1-1443	peptide-Asn1190+Cys-peptide	N	CS	Ile	Ser	His	Asn	Cys	Thr	Tyr	His
reverse gyrase	Q58907	1-1613	peptide-Leu866+Cys-peptide	N	CS	Glu	Leu	Gly	Leu	Cys	Leu	Thr	Pro
reverse gyrase	Q58907	1-1613	peptide-Asn1360+Cys-peptide	N	CS	Ile	Ser	His	Asn	Cys	Thr	Tyr	His
reverse gyrase	O58530	1-1624	peptide-Leu953+Cys-peptide	N	CS	Glu	Ala	Gly	Leu	Cys	Val	Thr	Pro
reverse gyrase	O58530	1-1624	peptide-Asn1363+Cys-peptide	N	CS	Val	Ser	His	Asn	Cys	Thr	Tyr	His
reverse gyrase	B7R1X7	1-1714	peptide-Leu960+Cys-peptide	N	CS	Glu	Ala	Gly	Leu	Cys	Val	Thr	Pro
reverse gyrase	B7R1X7	1-1714	peptide-Asn1448+Cys-peptide	N	CS	Val	Ser	His	Asn	Cys	Thr	Tyr	His
reverse gyrase	D2RI62	1-1566	peptide-Leu829+Cys-peptide	N	CS	Glu	Ser	Gly	Leu	Cys	Val	Thr	Pro
reverse gyrase	D2RI62	1-1566	peptide-Asn1317+Cys-peptide	N	CS	Leu	Asn	His	Asn	Cys	Thr	Tyr	His
translation initiation factor IF-2	Q2P9P8	1-523	peptide-Asn522+Thr	N	CS	Val	Val	His	Asn	Thr	-	-	-