Substrates for peptidase M9G.034: metallopeptidase ShpII (Staphylococcus hyicus)

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Glucagon	P01272	53-81	Peptide-Thr57+Phe-Peptide	N	NT	Ser	Gln	Gly	Thr	Phe	Thr	Ser	Asp	Ayora et al., 1994
Glucagon	P01272	53-81	Peptide-Tyr65+Leu-Peptide	N	NT	Tyr	Ser	Lys	Tyr	Leu	Asp	Ser	Arg	Ayora et al., 1994
Glucagon	P01272	53-81	Peptide-Arg70+Ala-Peptide	N	NT	Asp	Ser	Arg	Arg	Ala	Gln	Asp	Phe	Ayora et al., 1994
Glucagon	P01272	53-81	Peptide-Asp73+Phe-Peptide	N	NT	Arg	Ala	Gln	Asp	Phe	Val	Gln	Trp	Ayora et al., 1994
Glucagon	P01272	53-81	Peptide-Trp77+Leu-Peptide	N	NT	Phe	Val	Gln	Trp	Leu	Met	Asn	Thr	Ayora et al., 1994
Glucagon	P01272	53-81	Peptide-Gln76+Trp-Peptide	N	NT	Asp	Phe	Val	Gln	Trp	Leu	Met	Asn	Ayora et al., 1994
Insulin B chain (Oxidised)	P01317	25-54	Phe-Val-Asn-Gln-His+Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Val	Asn	Gln	His	Leu	Cya	Gly	Ser	Ayora et al., 1994
Insulin B chain (Oxidised)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Cya	Gly	Ser	His	Leu	Val	Glu	Ala	Ayora et al., 1994
Insulin B chain (Oxidised)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Ayora et al., 1994
Insulin B chain (Oxidised)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Glu	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Ayora et al., 1994
Insulin B chain (Oxidised)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu+Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Glu	Ayora et al., 1994
Insulin B chain (Oxidised)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly+Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Gly	Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Ayora et al., 1994
Insulin B chain (Oxidised)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Ayora et al., 1994
Insulin B chain (Oxidised)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala	N	NT	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Lys	Ayora et al., 1994
Lipase	P04635	39-641	Peptide-Thr245+Val-Peptide	P	NT	Lys	Lys	Pro	Thr	Val	Lys	Ala	Ala	Ayora et al., 1994
lipase precursor	P04635	39-641	peptide-Thr245+Val-peptide	P		Lys	Lys	Pro	Thr	Val	Lys	Ala	Ala	Ayora et al., 1994
Melittin	Q8LW54	51-76	Peptide-Val57+Leu-Peptide	N	NT	Ala	Val	Leu	Lys	Val	Leu	Thr	Thr	Ayora et al., 1994
Melittin	Q8LW54	51-76	Peptide-Ala65+Leu-Peptide	N	NT	Gly	Leu	Pro	Ala	Leu	Ile	Ser	Trp	Ayora et al., 1994
Melittin	Q8LW54	51-76	Peptide-Leu66+Ile-Peptide	N	NT	Leu	Pro	Ala	Leu	Ile	Ser	Trp	Ile	Ayora et al., 1994
Melittin	Q8LW54	51-76	Peptide-Ser68+Trp-Peptide	N	NT	Ala	Leu	Ile	Ser	Trp	Ile	Lys	Arg	Ayora et al., 1994
Melittin	Q8LW54	51-76	Peptide-Trp69+Ile-Peptide	N	NT	Leu	Ile	Ser	Trp	Ile	Lys	Arg	Lys	Ayora et al., 1994