Substrates for peptidase M9G.003: acrolysin

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
insulin A chain (oxidized) P01317 85-105 Gly+Ile-Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cya-Asn N - - - Gly Ile Val Glu Gln McRorie et al., 1976
[des-Gly1-Ile2]insulin A chain (oxidized) P01317 87-105 Val+Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cya-Asn N - - - Val Glu Gln Cya Cya McRorie et al., 1976
[des-Gly1]insulin A chain (oxidized) P01317 86-105 Ile+Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cya-Asn N - - - Ile Val Glu Gln Cya McRorie et al., 1976