Substrates for peptidase M34.002: Pro-Pro endopeptidase 1 (Clostridium difficile-type)

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
putative adhesin Q183R6 1-972 peptide-Pro835+Pro-peptide P MS Pro Val Asn Pro Pro Ala Pro Pro Hensbergen et al., 2014
putative adhesin Q183R6 1-972 peptide-Pro848+Pro-peptide P MS Ile Val Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative adhesin Q183R6 1-972 peptide-Pro874+Pro-peptide P MS Val Ile Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative adhesin Q183R6 1-972 peptide-Pro885+Pro-peptide P MS Ile Ile Asn Pro Pro Ile Pro Glu Hensbergen et al., 2014
putative adhesin Q183R6 1-972 peptide-Pro893+Pro-peptide P MS Val Leu Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative adhesin Q183R6 1-972 peptide-Pro936+Pro-peptide P MS Leu Val Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative surface protein Q17ZZ0 1-727 peptide-Pro585+Pro-peptide P MS Val Val Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative surface protein Q17ZZ0 1-727 peptide-Pro597+Pro-peptide P MS Val Val Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative surface protein Q17ZZ0 1-727 peptide-Pro623+Pro-peptide P MS Val Ile Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative surface protein Q17ZZ0 1-727 peptide-Pro635+Pro-peptide P MS Ile Ile Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative surface protein Q17ZZ0 1-727 peptide-Pro647+Pro-peptide P MS Val Leu Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative surface protein Q17ZZ0 1-727 peptide-Pro647+Pro-peptide P MS Val Leu Asn Pro Pro Val Pro Pro Hensbergen et al., 2014
putative surface protein Q17ZZ0 1-727 peptide-Pro671+Pro-peptide P MS Val Leu Asn Pro Pro Val Pro Pro Hensbergen et al., 2014